Predictive value of serum iron and soluble serum transferrin receptor detection for pregnancy outcome in pregnant women with anemia
Li Dan, Yang Xiaoqian, Cao Xueping
1. Department of Clinical Laboratory, the First Maternal and InfantHealth Hospital Affiliated to Tongji University, Shanghai 200040, China; 2.Department of Obstetrics and Gynecology, the First Maternal and Infant Health Hospital Affiliated to Tongji University, Shanghai 200040, China
Abstract: 【Abstract】 Objective To explore the relationship and clinical significance of serum iron (SI) and soluble serum transferrin receptor (sTfR) detection in pregnant women with anemia during pregnancy and pregnancy outcome. Method A total of 1 000 pregnant women from the First Maternal and Infant Health Hospital Affiliated to Tongji University from January 2020 to June 2021 were selected as the research objects.They were divided into anemia group (n=195) and non-anemia group (n=805) according to anemia or not.The general data, SI and sTfR levels of pregnant women in the two groups were compared. Follow-up was conducted until the end of pregnancy, and adverse pregnancy outcomes were compared between the two groups. SI and sTfR levels were compared among pregnant women with anemia for different pregnancy outcomes. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to evaluate the predictive value of SI and sTfR levels for pregnancy outcomes in anemic pregnant women.Statistical methods performed by independent sample t-test and χ2 test. Result The incidence of anemia during pregnancy was 19.50% (195/1 000). The level of SI in the anemia group was lower than that in the non-anemia group [(5.5±1.0) vs (18.2±6.0) μmol/L, t=29.370, P<0.001]. The level of sTfR was higher than that in the non-anemia group [(3.8±1.3) vs (1.9±0.6) mg/L, t=31.638, P<0.001]. The overall incidence of adverse pregnancy outcomes in the anemia group was higher than that in the non-anemia group [23.59%(46/195) vs 4.10% (33/805), χ2=81.957, P<0.05]. The level of SI of anemic pregnant women with and without adverse pregnancy outcome was [(4.6±0.8) vs (5.7±0.8) μmol/L, t=15.366, P<0.001], and the level of SI for anemic pregnant women with adverse pregnancy outcome was lower than that of anemic pregnant women without adverse pregnancy outcome. The level of sTfR was [(4.6±1.2) vs (3.6±1.0) mg/L, t=8.985, P<0.001], which was higher in the anemic pregnant women than that without adverse pregnancy outcomes.The AUC predicted by SI and sTfR alone was 0.743 and 0.770, respectively. The AUC predicted by SI and sTfR together was the largest (0.924), and the best diagnostic sensitivity and specificity were 80.43% and 87.92%, respectively. Conclusion The changes of SI and sTfR levels are closely related to the occurrence of anemia in pregnancy. Combined detection has a high predictive value for pregnancy outcomes in pregnant women with anemia, and can be used as an auxiliary index for early clinical evaluation and prediction.
李丹 杨小倩 曹雪萍. 贫血孕妇血清铁及可溶性血清转铁蛋白受体检测对妊娠结局的预测价值[J]. 发育医学电子杂志, 2024, 12(1): 30-35.
Li Dan, Yang Xiaoqian, Cao Xueping. Predictive value of serum iron and soluble serum transferrin receptor detection for pregnancy outcome in pregnant women with anemia. Journal of Developmental Medicine(Electronic Version), 2024, 12(1): 30-35.
2024, Vol. 12 
