(1. Beijing Key Laboratory of Pediatric Organ Failure, National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Institute of Pediatrics, the Seventh Medical Center of PLA General Hospital, Faculty of Pediatrics, the Chinese PLA General Hospital, Beijing 100700, China; 2. Department of Neonatology, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang, Urumqi 830054, China; 3. Department of Neonatology, Children’s Hospital of Chongqing Medical University, Chongqing 401122, China; 4. Department of Neonatology, the Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia, Huhhot 010050, China)
Research on the correlation between pulmonary surfactant protein B deficiency and neonatal respiratory distress syndrome in full-term newborns
Yin Xiaojuan, Li Mingxia, Shi Yuan, et al
(1. Beijing Key Laboratory of Pediatric Organ Failure, National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Institute of Pediatrics, the Seventh Medical Center of PLA General Hospital, Faculty of Pediatrics, the Chinese PLA General Hospital, Beijing 100700, China; 2. Department of Neonatology, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang, Urumqi 830054, China; 3. Department of Neonatology, Children’s Hospital of Chongqing Medical University, Chongqing 401122, China; 4. Department of Neonatology, the Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia, Huhhot 010050, China)
Abstract: 【Abstract】 Objective To explore the correlation between pulmonary surfactant protein (SP) -B deficiency and neonatal respiratory distress syndrome (NRDS) in full-term newborns. Method From July 2019 to June 2023, research was conducted in the Seventh Medical Center of PLA General Hospital and the other three hospitals. 60 full-term newborns who died with NRDS were included in the NRDS group. The control group included 60 full-term newborns with non-NRDS who died after surgery due to other reasons during the same period. Chest X-ray results were collected. Within 30 min after the newborns died, bronchoalveolar lavage and lung tissue sampling were performed. SP-B expression was detected using Western blotting. Chisquare test was used for statistical methods. Result Newborns in the NRDS group experienced severe hypercapnia and hypoxemia after birth. Adopting comprehensive treatment measures such as exogenous pulmonary surfactant, invasive high-frequency oscillatory ventilation respiratory support, nitric oxide therapy to reduce pulmonary arterial hypertension, etc. Ten cases received extracorporeal membrane oxygenation (ECMO). However, all of them died. Chest X-rays in the NRDS group all showed white lungs. The proportion of positive expression of SP-B monomers (molecular weight 8 ku) and dimers (molecular weight 16-18 ku) in bronchoalveolar lavage fluid of newborns in the NRDS group was significantly lower than that in the control group [8 ku: 75.0% (45/60) vs 100.0% (60/60), χ2=17.143; 16-18 ku: 73.3% (44/60) vs 100.0% (60/60),χ2=18.462; P<0.001]. The proportion of positive expression of SP-B monomers and dimers in lung tissue of the NRDS group was significantly lower than that of the control group [8 ku: 75.0% (45/60) vs 100.0% (60/60), χ2=17.143; 16-18 ku: 70.0% (42/60) vs 100.0% (60/60), χ2=21.176; P<0.001]. Fifteen newborns with SP-B deficiency were detected in the NRDS group, while one with SP-B deficiency was detected in the control group. The proportion of SP-B deficiency in the NRDS group was significantly higher than that in the control group [25.0% (15/60) vs 1.7% (1/60), χ2=14.135, P<0.001]. Conclusion SP-B deficiency is corrected with NRDS in full-term newborns to some extent.
尹晓娟 李明霞 史源 梅花 张晓媛 朱艳萍 霍梦月 封志纯. 肺表面活性物质蛋白- B 缺陷与足月新生儿呼吸窘迫综合征的相关性研究[J]. 发育医学电子杂志, 2024, 12(1): 25-29.
Yin Xiaojuan, Li Mingxia, Shi Yuan, et al. Research on the correlation between pulmonary surfactant protein B deficiency and neonatal respiratory distress syndrome in full-term newborns. Journal of Developmental Medicine(Electronic Version), 2024, 12(1): 25-29.
2024, Vol. 12 
