发育医学电子杂志 Vol. 12 374-379 DOI: 10.3969/j.issn.2095-5340.2024.05.009
结构畸形
综述
新生儿坏死性小肠结肠炎与肠道菌群的 研究进展
韩金宝 黄柳明
国家儿童医学中心 首都医科大学附属北京儿童医院 急诊外 科， 北京 100045
Research progress on neonatal necrotizing enterocolitis and intestinal flora
Han Jinbao, Huang Liuming
Department of Emergency Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
摘要 【摘要】 新生儿坏死性小肠结肠炎(necrotizing enterocolitis，NEC) 常见于早产儿和低出生体质量儿，是新生儿重症监护病房中发病率及死亡率最高的疾病。NEC 在早产儿、低出生体质量儿中常起病隐匿，进 展迅速，在新生儿早期即造成患儿死亡或存在严重后遗症。目前，已有多项研究证实，肠道菌群与NEC 的发生有密切关系，在NEC 发作之前，婴幼儿粪便菌中变形菌门的相对丰度增加，而厚壁菌门和拟杆菌 门降低；低菌群多样性、低乳杆菌属丰度及菌群网络结构的变化与早产儿的NEC 风险呈正相关。因此 了解NEC 患儿小肠内菌群分布特点对于疾病的预防、诊断和治疗具有重要作用。深入研究小肠菌群与 NEC 的相互作用关系，为NEC 的进一步研究提供理论依据。
关键词:
新生儿
坏死性小肠结肠炎
肠道菌群
菌群多样性
Abstract: 【Abstract】 Neonatal necrotizing enterocolitis (NEC) was common in premature infants and low birth weightinfants, which was the disease with the highest morbidity and mortality in neonatal intensive care units. NEC often had an insidious onset and rapid progression in premature infants and low birth weight infants, causing death or serious sequelae in the early neonatal period. Currently, many studies had confirmed that intestinal flora was closely related to the occurrence of NEC. Before the onset of NEC, the relative abundance of Proteobacteria in infant fecal bacteria increases, while Firmicutes and Bacteroidetes decrease; low flora diversity, low Lactobacillus abundance, and changes in flora network structure were positively correlated with the risk of NEC in premature infants. Therefore, understanding the distribution characteristics of intestinal flora in children with NEC was important for prevention, diagnosis, and treatment of the disease. In-depth study of the interaction between intestinal flora and NEC provides a theoretical basis for further research on NEC.
Key words:
Neonate
Necrotizing enterocolitis
Intestinal flora
Flora diversity
收稿日期: 2024-05-30
出版日期: 2024-09-30
发布日期: 2024-09-30
期的出版日期: 2024-09-30
基金资助: 军委后勤保障部卫生局应用基础研究项目（21JSZ18）
通讯作者:
黄柳明
E-mail: surhlm@126.com
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