发育医学电子杂志 2019, Vol. 7 Issue (2): 95-99 DOI: 10.3969/j.issn.2095-5340.2019.02.004
结构畸形
专题笔谈
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MTHFR 基因多态性与男性不育
姚晓阳 刘明华 马龙 颜宏利
1. 海军军医大学附属长海医院 生殖医 学中心,上海 200433;2. 上海中医药大学附属第七人民医院 检验科,上海 200137)
MTHFR gene polymorphism and male infertility
YAO Xiao-yang, LIU Ming-hua, MA Long, et al
摘要 不孕不育是一个多因素导致的全球性健康难 题,全世界 10% ~ 15% 的夫妇不孕不育,其中大 约三分之一是由于男性因素导致[1] 。近 8% 的育 龄男性为不育相关问题寻求医疗咨询[2] 。男性不 育主要表现为精子发生缺陷[3] ,其原因可部分归 因于神经因素、生殖器肿瘤、生殖细胞再生障碍、 精子运输缺陷、精索静脉曲张或环境毒素。虽然 现代医疗诊断和大量的研究已经解释了部分男性 不育的发病机制,但仍有大约 50% 的不育病例未 得到解释[4-6] 。近年来,许多研究分析了亚甲基 四 氢 叶 酸 还 原 酶(5,10-methylenetetrahydr-ofolate reductase,MTHFR)基因多态性与男性不育的关系。
关键词:
男性不育')" href="#"> 男性不育
MTHFR')" href="#"> MTHFR
')" href="#"> 基因多态性
C677T')" href="#"> C677T
A1298C')" href="#"> A1298C
收稿日期: 2019-01-18
出版日期: 2019-04-30
发布日期: 2019-05-06
期的出版日期: 2019-04-30
基金资助: 国家重点研发计划(SQ2018YFC100248)
通讯作者:
颜宏利https://baike.baidu.com/item/%E9%A2%9C%E5%AE%8F%E5%88%A9/8414418?fr=aladdin
E-mail: 13321804529@163.com
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