男性不育, MTHFR, 基因多态性, C677T, A1298C," />  男性不育, MTHFR, 基因多态性, C677T, A1298C,"/> <span style="line-height:2;font-size:14px;">MTHFR 基因多态性与男性不育</span>
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发育医学电子杂志  2019, Vol. 7 Issue (2): 95-99    DOI: 10.3969/j.issn.2095-5340.2019.02.004
  结构畸形   专题笔谈 |
MTHFR 基因多态性与男性不育
姚晓阳  刘明华 马龙 颜宏利
1. 海军军医大学附属长海医院 生殖医学中心,上海 200433;2. 上海中医药大学附属第七人民医院 检验科,上海 200137)
MTHFR gene polymorphism and male infertility
YAO Xiao-yang, LIU Ming-hua, MA Long, et al
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摘要 不孕不育是一个多因素导致的全球性健康难题,全世界 10% ~ 15% 的夫妇不孕不育,其中大约三分之一是由于男性因素导致[1]。近 8% 的育龄男性为不育相关问题寻求医疗咨询[2]。男性不育主要表现为精子发生缺陷[3],其原因可部分归因于神经因素、生殖器肿瘤、生殖细胞再生障碍、精子运输缺陷、精索静脉曲张或环境毒素。虽然现代医疗诊断和大量的研究已经解释了部分男性不育的发病机制,但仍有大约 50% 的不育病例未得到解释[4-6]。近年来,许多研究分析了亚甲基四 氢 叶 酸 还 原 酶(5,10-methylenetetrahydr-ofolate reductase,MTHFR)基因多态性与男性不育的关系。
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关键词:   男性不育')" href="#"> 男性不育  MTHFR')" href="#"> MTHFR  ')" href="#"> 基因多态性  C677T')" href="#"> C677T  A1298C')" href="#"> A1298C    
收稿日期:  2019-01-18                出版日期:  2019-04-30      发布日期:  2019-05-06      期的出版日期:  2019-04-30
基金资助: 国家重点研发计划(SQ2018YFC100248)
通讯作者:  颜宏利https://baike.baidu.com/item/%E9%A2%9C%E5%AE%8F%E5%88%A9/8414418?fr=aladdin    E-mail:  13321804529@163.com
引用本文:    
姚晓阳 刘明华 马龙 颜宏利 . MTHFR 基因多态性与男性不育[J]. 发育医学电子杂志, 2019, 7(2): 95-99.
YAO Xiao-yang, LIU Ming-hua, MA Long, et al. MTHFR gene polymorphism and male infertility. Journal of Developmental Medicine(Electronic Version), 2019, 7(2): 95-99.
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http://www.fyyxzz.com/CN/10.3969/j.issn.2095-5340.2019.02.004  或          http://www.fyyxzz.com/CN/Y2019/V7/I2/95
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