发育医学电子杂志  2022, Vol. 10 Issue (1): 64-69 DOI: 10.3969/j.issn.2095-5340.2022.01.012 |
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围产医学
综述
｜产科
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| 流产型未分化结缔组织病的研究现状及展望 |
| 高睿 秦朗 |
（1. 四川大学华西第二医院 妇产科 生殖医学中心，四川 成都 610041；2. 四川大学华西临床医学院，四川 成都 610041；3. 四川大学华西第二 医院 出生缺陷与相关妇儿疾病教育部重点实验室，四川 成都 610041）
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| Research status and prospect of abortion-type undifferentiated connective tissue disease |
| Gao Rui , Qin Lang |
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摘要 未分化结缔组织病（undifferentiated connective tissue disease， UCTD）是一组异质性较强的全身性自身免疫性疾病，表现为至少1 种结缔组织病的症 状或体征的存在，同时伴有自身抗体检查的异常，但不满足任何其他结缔组织病的诊断标准［1-4］。芬兰、意大利及美国的调查数据均显示，UCTD 是人群中发病率最高的风湿免疫疾病之一［5-6］，男女发病率之比在1 ∶ 15 ～ 1 ∶ 17［7-10］，也是妊娠期女性最常发生的全身性自身免疫疾病，患病率达2.5%［11］。目前认为UCTD 作为一种独立的疾病，有向其他结缔组织病分化的潜力，约1/3 的UCTD 会在数月或数年后分化为特定的结缔组织病，如系统性红斑狼疮（systemic lupus erythematosus，SLE）、类风湿关节炎（rheumatoid arthritis， RA）、抗磷脂综合征（antiphospholipid syndrome， APS）及干燥综合征（sjogren syndrome， SS）等，但大部分UCTD 会长期 维持较低的活动度，甚至终身不进展［1-2，4，12］。
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| 关键词:
未分化结缔组织病
类风湿关节炎
统性红斑狼疮
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收稿日期: 2020-10-16
发布日期: 2022-01-28
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| 基金资助: 四川省卫生健康委员会项目（20PJ072） |
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通讯作者:
秦朗
E-mail: cacier@163.com
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