Progress and challenges in mitochondria-based multi-omics mass spectrometry
Yan Lei, Li Jun, Wang Yi, et al.#br#
Institute of Pediatrics, the Seventh Medical Center of PLA General Hospital, National Engineering Laboratory for Key Technologies of Birth Defects Prevention and Control, Beijing Key Laboratory of Pediatric Critical Care and Rehabilitation, Beijing 100700, China
As the cellular powerhouse and signaling hub, mitochondrial dysfunction is intimately associated with a broad spectrum of diseases. Mitochondrial multi-omics analysis provides a powerful tool for understanding mitochondria at the systems biology level. This review presents the latest advances in mitochondrial multi-omics mass spectrometry technologies, focusing on breakthroughs in technical integration, data acquisition, and biological discovery. It also analyzes current technical challenges and difficulties in biological interpretation, and offers perspectives on future directions.
2026, Vol. 14 
