骨髓增生异常综合征在斑马鱼中的研究进展

doi:10.3969/j.issn.2095-5340.2024.01.010

发育医学电子杂志

2024, Vol. 12

Issue (1): 53-60 DOI: 10.3969/j.issn.2095-5340.2024.01.010

临床遗传综述

骨髓增生异常综合征在斑马鱼中的研究进展

易可欣　范尹尹　陈柳蓉　汪玉宝　朱文武　贾海波　朱雄伟

（1. 华中科技大学　生命科学与技术学院，湖北　武汉　430074 ； 2. 武汉鹰达生物科技有限公司，湖北　武汉　430200 ； 3. 武汉工程大学　环境生态与生物工程学院，湖北　武汉 430205）

Research progress of myelodysplastic syndrome in zebrafish

Yi Kexin, Fan Yinyin, Chen Liurong. et al

(1. Collegeof Life Science and Technology, Huazhong University of Science and Technology, Hubei, Wuhan 430074,China; 2. Wuhan Eagle Biotechnology Co, Ltd, Hubei, Wuhan 430200, China; 3. School of EnvironmentalEcology and Biological Engineering, Wuhan Institute of Technology, Hubei, Wuhan, 430205, China)

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摘要【摘要】骨髓增生异常综合征（myelodysplastic syndrome，MDS）是一种常见的血液疾病，其发病率呈现逐年上升的趋势。斑马鱼作为一种生物医学研究的模式生物，广泛应用于各类疾病的研究中。本文关注
了近年来血液疾病在斑马鱼中的研究，MDS 在小鼠、大鼠和斑马鱼中的研究及动物模型的应用，揭示了
斑马鱼模型在其中发挥的重要作用。

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关键词: 骨髓增生异常综合征斑马鱼动物模型血液肿瘤疾病药物筛选

Abstract: 【Abstract】Myelodysplastic syndrome (MDS) is a prevalent hematologic disorder, with its incidence
steadily increasing. Zebrafish, as an established model organism in biomedical research, has been extensivelyutilized for investigating various diseases. This review specifically focuses on the research of blood diseasesin zebrafish in recent years, the study of MDS in mice, rats and zebrafish and the application of animalmodels, showing the important role played by zebrafish models among them.

Key words: Myelodysplastic syndrome Zebrafish Animal model; Hematologic oncologic disease Drugscreening

收稿日期: 2023-10-07 发布日期: 2024-01-31

基金资助: 国家自然科学基金（81770102）；华中科技大学重点研发项目（2018YFA0801000）

通讯作者: 贾海波 E-mail: haibo.jia@hust.edu.cn

引用本文:

易可欣　范尹尹　陈柳蓉　汪玉宝　朱文武　贾海波　朱雄伟. 骨髓增生异常综合征在斑马鱼中的研究进展[J]. 发育医学电子杂志, 2024, 12(1): 53-60.
Yi Kexin, Fan Yinyin, Chen Liurong. et al. Research progress of myelodysplastic syndrome in zebrafish. Journal of Developmental Medicine(Electronic Version), 2024, 12(1): 53-60.

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