发育医学电子杂志  2022, Vol. 10 Issue (1): 7-11 DOI: 10.3969/j.issn.2095-5340.2022.01.002 |
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发育基础
专题笔谈
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| 斑马鱼血液疾病模型 |
| 明邦发 王欢 陈柳蓉 贾海波 王雅琴 |
（1. 华中科技大学 生命科学与技术学院，湖北 武汉 430074 ﹔ 2. 华中科技大学同济医学院附属同济医院 儿科,
湖北 武汉 430030）
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| Zebrafish disease models in hematology |
| Ming Bangfa, Wang Huan, Chen Liurong, et al |
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摘要 血液细胞发育受到造血干细胞和微环境之间复杂相互作用的严格调控，使得在模式生物中的体内研究成为必要。因此针对血液疾病的关键致病因子构建动物模型，对于人类疾病机制研究、治疗及药物评价至关重要斑马鱼，学名Daniorerio，作为研究造血系统发育和疾病的优良模式生物，其造血系统的发育过程及分子机制在高等脊椎动物中是保守的，同时斑马鱼进行正向和反向遗传筛选的可能性以及其胚胎和幼体的光学透明等优点使其成为造血发育的体内分析的理想材料。斑马鱼造血系统的缺陷能够准确可靠地再现人类血液疾病，可以为研究血液发育疾病表型并设计治疗策略提供模型系统，可用于疾病发生发展的体内可视化研究，为在体内研究血液疾病的基因和表型关系，并且为疾病药物筛选和评估提供可能。本文讨论了主要血液疾病所现有的斑马鱼模型，这些血液疾病包括髓系肿瘤、淋巴肿瘤、贫血等，并对这些模型的构建途径进行简要述。
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| 关键词:
斑马鱼
模式生物
造血系统疾病
动物模型
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收稿日期: 2021-12-07
发布日期: 2022-01-28
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| 基金资助: 国家自然科学基金（81400086；81770102）；国家重点研发项目（2018YFA 0801000） |
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通讯作者:
贾海波，王雅琴
E-mail: haibo.jia@hust.edu.cn，wangyaq@163.com
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