Application effect of the early screening scale for autism spectrum disorder in pediatrichealth clinics
Zhang Ying, Fu Yunrong, Li Yuxian, et al
1.Department of Child Health Care, Jinniu Maternityand Child Health Hospital of Chengdu, Sichuan, Chengdu 610000, China; 2.Department of Child HealthCare, Chengdu Women's and Children's Central Hospital, Affiliated Women's and Children's Hospital, Schoolof Medicine, University of Electronic Science and Technology of China, Sichuan, Chengdu 611731, China
Abstract: 【Abstract】 Objective To explore the early screening method of autism spectrum disorder (ASD) suitable for primary hospitals, and improve the ability of primary doctors to identify ASD. Method A total of 2 437 children aged 18-30 months who received regular child health care in the Jinniu Maternity and Child Health Hospital of Chengdu from October 2020 to July 2021 were retrospectively selected as the research objects. In order to screen ASD, the primary screening methods of the checklist for autism in toddlers-23 (Chat-23) scale, the ASD early warning inquiry and field observation were applied. A total of 31 children with positive results and confirmed dysplasia were evaluated using the symbolic play test (SPT) and the infant language development screening scale to explore the early ASD screening methods for primary care hospital. Statistical methods performed by One-way analysis of variance, χ2 test, Fisher exact probability method and receiver operating characteristic (ROC) curve analysis. Result In the boys, the positive rates of part A of Chat-23 scale [2.11% (27/1 281) vs 0.95% (11/1 156), χ2=5.292, P=0.021] and the positive rates of part B of Chat-23[2.03% (26/1 281) vs 0.61% (7/1 156), χ2=9.226, P=0.002] were significantly higher than those of girls. There was no significant difference in the positive rates of part A and part B of Chat-23 scale in children of different ages (all P>0.05). There was no statisticant significance in the positive rates of the ASD early warning and field observation among children of different genders and ages (all P>0.05). ROC curve analysis showed thatthe area under the curve (AUC) of Chat-23 scale for screening ASD was 0.946, the sensitivity was 90.00%,and the specificity was 99.18% (P<0.05). The scores of SPT scale and part B of infant language developmentscreening scale in children with ASD were significantly lower than those in children with global developmentdelay and language development delay, and the differences were statistically significant (all P<0.05). Therewere no significant differences in the scores of part A and part C of infant language development screeningscale among the three groups of children (all P>0.05). Conclusion Chat-23 scale can be used for earlyscreening of ASD in primary hospitals. The combination of SPT scale and infant language development screening scale can improve the differential diagnosis ability of doctors in primary hospitals for ASD.
张颖 付云蓉 李玉仙 杨文旭. 孤独症谱系障碍早期筛查量表在儿童保健门诊的应用效果[J]. 发育医学电子杂志, 2025, 13(1): 19-25.
Zhang Ying, Fu Yunrong, Li Yuxian, et al. Application effect of the early screening scale for autism spectrum disorder in pediatrichealth clinics. Journal of Developmental Medicine(Electronic Version), 2025, 13(1): 19-25.
2025, Vol. 13 
