发育医学电子杂志 Vol. 3 79-82
围产医学
论著
｜产科
虾青素对体外受精 - 胚胎移植失败 患者卵巢反应性的临床观察
徐晨 李文 孙宁霞 章青 路新梅 王亮 庞文娟
徐晨 李文 孙宁霞 章青 路新梅 王亮 庞文娟（第二军医大学附属长征医院 生殖医学中心，上海 200003）
Clinical observation of astaxanthin to embryo transplant failure in patients of IVF-ET with ovarian response
XU Chen ,LI Wen ,SUN Ning-xia ,ZHANG Qing ,LU Xin-mei ,WANG Liang, PANG Wen-juan
XU Chen ,LI Wen ,SUN Ning-xia ,ZHANG Qing ,LU Xin-mei ,WANG Liang, PANG Wen-juan(Center for Reproductive Medicine,Shanghai Changzheng Hospital,Second Military Medical University,Shanghai 200003,China)
摘要 目的 探讨虾青素对卵巢储备功能降低（diminished ovarian reserve，DOR）患者行体外受精 -胚胎移植（in vitro fertilization and embryo transfer，IVF）治疗结局的影响。方法 对接受体外受精 / 卵胞浆内单精子注射（iVF/ intracytoplasmic sperm injection，ICSI）助孕治疗的 30 例 DOR 患者辅助 治疗前后周期进行自身对照研究 , 分析卵巢储备功能指标（基础激素水平、窦卵泡计数等）及周期治 疗参数（卵泡数、获卵数、受精率、胚胎种植率、临床妊娠率、周期取消率、流产率等）的变化。 结果 前后周期超促排卵方案差异无显著性 , 虾青素辅助治疗后基础窦卵泡计数、卵泡数、获卵数显著增加（P<0.05），胚胎种植率、临床妊娠率显著提高（P<0.05），周期取消率呈降低趋势（P>0.05）， 而受精率、流产率无差异（P>0.05）。结论 虾青素辅助治疗可以改善 DOR 患者卵巢储备功能 , 提高 卵巢反应性 , 改善 IVF 治疗结局。
关键词:
虾青素 ')" href="#">虾青素
体外受精 - 胚胎移植
卵巢储备功能降低
Abstract: Objective To discuss the influence of astaxanthin on outcome of diminished ovarian reserve patients in vitro fertilization-embryo transfer(IVF-ET). Method Self-control study was done on 30 DOR patients of the in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment before and after the acceptance of assisted reproductive cycles. Analyze ovarian reserve index (base hormone levels, antral follicle count,etc.)and cycle treatment parameters (number of follicles, oocytes, fertilization rate, embryo implantation rate, clinical pregnancy rate, cycle cancellation rate, abortion rate, etc.) change. Results The control ovarian hyperstimulation program between the previous cycle and the next cycle has no significant difference. After the treatment of astaxanthin，based antral follicle count, the number of follicles, implantation rate, clinical pregnancy rate and the number of oocytes significantly increase(P<0.05) with cycle cancellation rate significantly decreased(P>0.05). The fertilization rate and abortion rate has no difference (P>0.05). Conclusions Astaxanthin can improve ovarian reserve function of DOR patient, the ovarian reactivity and IVF treatment outcome
Key words:
Astaxanthin ')" href="#">Astaxanthin
In vitro fertilization-embryo transfer
Diminished ovarian reserve
收稿日期: 2015-04-02
出版日期: 2015-04-30
发布日期: 2018-05-25
期的出版日期: 2015-04-30
通讯作者:
李文http://www.cnkang.com/yyk/docindex/38582/#
E-mail: lyyliwen@sina.com
引用本文:
徐晨 李文 孙宁霞 章青 路新梅 王亮 庞文娟. 虾青素对体外受精 - 胚胎移植失败 患者卵巢反应性的临床观察 [J]. 发育医学电子杂志, 2015, 3(2): 79-82.
Clinical observation of astaxanthin to embryo transplant failure in patients of IVF-ET with ovarian response . Journal of Developmental Medicine(Electronic Version), 2015, 3(2): 79-82.
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