新生儿缺氧缺血综合征的研究进展

doi:10.3969/j.issn.2095-5340.2019.01.005

发育医学电子杂志

2019, Vol. 7

Issue (1): 19-23 DOI: 10.3969/j.issn.2095-5340.2019.01.005

围产医学母源性疾病｜新生儿

新生儿缺氧缺血综合征的研究进展

廖正嫦　岳少杰

中南大学湘雅医院　新生儿科，湖南　长沙　410008

Research progress on neonatal hypoxic ischemic syndrome

LIAO Zheng-chang YUE Shao-jie

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摘要新生儿缺氧缺血综合征是指新生儿因缺氧缺血引起机体一系列病理生理变化，常表现为多器官功能损害，是导致新生儿死亡、脑瘫和智力发育障碍的主要原因之一。围产期缺氧缺血主要包括胎儿窘迫及出生时窒息。胎儿窘迫是胎儿在宫内缺氧出现胎心率异常、羊水粪染及胎动减少的一种危急状态；出生时窒息常为胎儿窘迫的延续，由于宫内缺氧导致新生儿出生时不能建立正常的呼吸，从而导致出生时窒息。缺氧缺血综合征发病的核心是缺氧，缺氧早期机体的“脑保护效应”可导致血流重新分配，减少了肾、肺、胃肠等器官血流。随着缺氧进一步加重，机体的代偿能力耗竭，从而发生多器官功能损害。存活者常存在严重的神经系统后遗症，极大地影响新生儿的生存质量。因此，围产期缺氧缺血综合征已越来越引起产科及新生儿科领域的高度重视。

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	廖正嫦　岳少杰

关键词: 新生儿')" href="#">新生儿缺氧缺血综合征多器官功能损害防治

收稿日期: 2018-11-12 出版日期: 2019-01-30 发布日期: 2019-02-01 期的出版日期: 2019-01-30

基金资助: 国家自然科学基金（81370098、81801510）

通讯作者: 岳少杰https://baike.baidu.com/item/%E5%B2%B3%E5%B0%91%E6%9D%B0/10208760?fr=aladdin E-mail: shaojieyue@163.com

引用本文:

廖正嫦　岳少杰. 新生儿缺氧缺血综合征的研究进展[J]. 发育医学电子杂志, 2019, 7(1): 19-23.
LIAO Zheng-chang YUE Shao-jie. Research progress on neonatal hypoxic ischemic syndrome. Journal of Developmental Medicine(Electronic Version), 2019, 7(1): 19-23.

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