Pathogen distribution and epidemic characteristics of acute respiratory infection in children in Baotou, Inner Mongolia
Zhao Changliang, Jiang Haiyan, Wu Yue, et al
(1. Department of Pediatrics, Baotou Steel Group ThirdStaff Hospital, Inner Mongolia, Baotou 014010, China; 2. Epidemiology Department, Zhejiang University of Traditional Chinese Medicine, Zhejiang, Hangzhou 310000, China)
Abstract: 【Abstract】 Objective To analyze the pathogen distribution and epidemic characteristics of acute respiratory infection (ARI) in children in Baotou, Inner Mongolia. Method Nasopharyngeal swabs collected from 40 180 ARI children aged 0-12 years from 7 tertiary hospitals in Baotou city from July 1, 2016 to June 30, 2021 were included in the study, and grouped by gender, age, season and year. The high throughput fluorescence gene microarray technique was used to detect 34 subtypes of 26 pathogens. Statistical method performed by χ2 test. Result Pathogens were detected in 32 887 of 40 180 samples, the detectionrate was 81.85%. Among them, 16 289 cases (49.53%) were infected with single pathogen, 11 679 cases(35.51%) were infected with double pathogen, and 4 919 cases (14.96%) were infected with triple or more pathogens. A total of 58 993 pathogen strains were detected, among which the bacterial detection rate was 66.69% (26 798/40 180). The virus detection rate was 71.89% (28 884/40 180). The top three bacteria were Streptococcus pneumoniae, haemophilus influenzae and hemolytic streptococcus. The top three viruses were respiratory syncytial virus, parainfluenza virus and adenovirus. There were 22 727 males (56.56%) and 17 453 females (43.44%); the detection rates of viruses and bacteria in males were greater than those in females, the differences were statistically significant (χ2= 32.180, 5.645, P<0.05). Children with age <3 years accounted for 69.35% (27 865/40 180), the detection rates of the viruses, bacteria, candida albicans, mycoplasma pneumoniae were higher than those in children with ≥3 years old (χ2= 1 505.948, 4 613.823, 48.792, 361.449, all P<0.001). 10 858 (27.02%) samples were collected in spring, 7 048 (17.54%) samples in summer, 9 765 (24.30%) samples in autumn, and 12 509 (31.13%) samples in winter. In addition to Klebsiella pneumoniae, the distribution of other pathogens in different seasons was compared, all the differences were statistically significant (all P<0.05). Streptococcus pneumoniae was the main infection throughout the year. Among the virus infections, parainfluenza virus was the main virus in spring and autumn, adenovirus in summer and respiratory syncytial virus in winter. The difference of pathogen detection rate in different years was statistically significant (P<0.001). Streptococcus pneumoniae was the pathogen with the highest proportion of infections from 2016 to 2021. Conclusion In Baotou, Inner Mongolia, the main pathogens of ARI children aged 0-12 years are viruses, followed by bacteria and mycoplasma pneumoniae. The incidence of ARI in male children is higher than that in female children; children with age <3 years is higher than that of ≥3 years; winter and spring are higher than summer and autumn, so medical workers should pay more attention to them.
赵常亮 蒋海燕 吴玥 刘利军. 内蒙古自治区包头市儿童急性呼吸道感染病原体分布及流行特征[J]. 发育医学电子杂志, 2023, 11(2): 119-124.
Zhao Changliang, Jiang Haiyan, Wu Yue, et al. Pathogen distribution and epidemic characteristics of acute respiratory infection in children in Baotou, Inner Mongolia. Journal of Developmental Medicine(Electronic Version), 2023, 11(2): 119-124.
2023, Vol. 11 
