微小RNA 在妊娠期糖尿病发病机制及并发症中的作用

doi:10.3969/j.issn.2095-5340.2024.03.012

发育医学电子杂志

2024, Vol. 12

Issue (3): 229-234 DOI: 10.3969/j.issn.2095-5340.2024.03.012

围产医学综述｜产科

微小RNA 在妊娠期糖尿病发病机制及并发症中的作用

孙超颖　马丹丹　赵娥　侯海燕

（1. 天津市人民医院　产科，天津　300121 ；2. 天津医科大学第二医院　生殖医学与计划生育科，天津　300211）

Role of microRNA in pathogenesis and complications of gestational diabetes mellitus

Sun Chaoying, Ma Dandan, Zhao E, et al

(1. Department of Obstetrics, Tianjin People's Hospital,Tianjin 300121, China; 2. Department of Reproductive Medicine and Family Planning, the Second Hospital of Tianjin Medical University, Tianjin 300211, China)

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摘要 【摘要】 妊娠期糖尿病（gestational diabetes mellitus，GDM）是全球范围内日益严重的公共卫生问题之一，威胁着孕产妇和新生儿的健康。通过发现其病理生理机制，在预防及降低妊娠并发症的发生方面更有
针对性。近年来，微小RNA（microRNA，miRNA）作为最常见的表观遗传机制之一，在妊娠相关疾病（包
括GDM）的病理生理中发挥了重要作用。本综述旨在分析miRNA 在GDM 孕产妇中的变化，重点展示
miRNA 作为生物标志物对预测或诊断GDM 以及预测疾病预后的潜力，更有助于探究GDM 的发病机制及预防措施。

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关键词: 微小RNA 妊娠期糖尿病妊娠发病机制并发症

Abstract: 【Abstract】Gestational diabetes mellitus (GDM) is a growing public health problem worldwide, threateningmaternal and newborn health. Through the discovery of its pathophysiological mechanism, it is more targeted in preventing and reducing the occurrence of pregnancy complications. In recent years, microRNA (miRNA),as one of the most common epigenetic mechanisms, have played an important role in the pathophysiology ofpregnancy-related diseases, including GDM. The purpose of this review is to analyze the changes of miRNA in pregnant women with GDM, focusing on the potential of miRNA as a biomarker to predict or diagnose GDM and predict the prognosis of the disease, and to help us explore the pathogenesis and prevention measures of GDM.

Key words: MicroRNA Gestational diabetes mellitus Pregnancy Pathogenesis Complication

收稿日期: 2024-01-04 发布日期: 2024-06-01

基金资助: 中国博士后科学基金（2013M542479）

通讯作者: 侯海燕 E-mail: houhy2012@hotmail.com

引用本文:

孙超颖　马丹丹　赵娥　侯海燕. 微小RNA 在妊娠期糖尿病发病机制及并发症中的作用[J]. 发育医学电子杂志, 2024, 12(3): 229-234.
Sun Chaoying, Ma Dandan, Zhao E, et al. Role of microRNA in pathogenesis and complications of gestational diabetes mellitus. Journal of Developmental Medicine(Electronic Version), 2024, 12(3): 229-234.

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http://www.fyyxzz.com/CN/10.3969/j.issn.2095-5340.2024.03.012 或 http://www.fyyxzz.com/CN/Y2024/V12/I3/229

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