Research progress on factors influencing brain injury during cardiopulmonary bypass surgery in children with congenital heart disease
Yi Hui, Kan Fuquan, Wan Lei,et al.
1. Division of Pediatric Cardiology, Department of Pediatric Medicine, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China; 2. PLA Medical School, Beijing 100853, China; 3.Department of Cardiovascular Medicine, the First Medical Center of PLA General Hospital, Beijing 100853, China
Congenital heart disease (CHD) is the most common congenital disease in children, and cardiopulmonary bypass (CPB) is a key technique for the correction of CHD, but the brain injury caused by CPB is still an important cause of postoperative neurodevelopmental disorders, which not only affects the cerebral hemodynamics, but also may lead to long-term cognitive dysfunction and permanent neurological
impairment in the postoperative period. This paper systematically review the pathological mechanisms of
CPB-associated brain injury, focusing on the analysis of surgical factors, individual characteristics of children, inflammatory oxidative stress and neuroprotective strategies, in order to provide a theoretical basis for the optimization of perioperative management.
2026, Vol. 14 
