发育医学电子杂志 2023, Vol. 11 Issue (6): 466-470 DOI: 10.3969/j.issn.2095-5340.2023.06.011
生长发育
综述
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儿童脓毒症诊疗进展
许靖 孔祥永 张程和 雍亚云 柯海琳
(1. 广西中医药大学第一附属医院 儿科,广西 南宁 530023 ;2. 解放军总医院儿科医学部 解放军总医院第七医学 中心 新生儿重症监护病房,北京 100700)
Progress in diagnosis and treatment of sepsis in children
Xu Jing, Kong Xiangyong, Zhang Chenghe, et al
摘要 脓毒症是严重感染引起的临床综合征,其 特征是并发于全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)的免疫 失调、微循环紊乱/障碍和多器官功能障碍,如 果伴有心血管功能障碍、急性呼吸窘迫综合征 (acute respiratory distress syndrome,ARDS)或 2个以上器官/系统出现功能障碍,则为严重脓毒血 症[1-2] 。全球每10万活产新生儿中有2 202例发生脓 毒症[1] ,是儿童入住儿科重症监护室(pediatric intensive care unit,PICU)和死亡的主要原因之 一。全球儿童脓毒症的总体疾病负担很重,并存
在巨大的地区差异。一项纳入26个国家128家医疗 中心的横断面研究证实,PICU严重脓毒症的患病率
与经济社会发展水平有关。发达国家严重脓毒症发 生率为6%~8%,死亡率为21%~32%;而亚洲和南美
洲的发生率为15%~16%,死亡率分别为40%和11%; 南非的发生率为25%,死亡率为40%[3] 。我国儿童脓 毒症每年有360 000例以上,发生率约为1.8‰[4] 。
关键词:
脓毒症
儿童
诊断
治疗
收稿日期: 2023-04-17
出版日期: 2023-11-30
发布日期: 2023-11-29
期的出版日期: 2023-11-30
基金资助: 广西自然科学基金中医药壮瑶医药联合专项(2023GXNSFAA026296)
通讯作者:
孔祥永
E-mail: sdkongxy@126.com
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