体外激活治疗早发性卵巢功能不全的研究进展

doi:10.3969/j.issn.2095-5340.2022.01.011

发育医学电子杂志

2022, Vol. 10

Issue (1): 58-63 DOI: 10.3969/j.issn.2095-5340.2022.01.011

生殖胚胎综述

体外激活治疗早发性卵巢功能不全的研究进展

李紫袁　李文

海军军医大学附属长征医院　生殖医学中心，上海　200003

Advances of in vitro activation for premature ovarian insufficiency

Li Ziyuan, Li Wen

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摘要早发性卵巢功能不全（premature ovarian insufficiency，POI）是指女性在40岁前出现卵巢功能衰退，以月经紊乱（闭经或少经）和卵泡储备减少为主要特征。根据2016 年欧洲人类生殖与胚胎学年会发表的临床指南标准：①少经或闭经4个月以上；②连续2次检查（间隔>4周）促卵泡激素(follicle-stimulating hormone, FSH) >25 U/L，即临床诊断为POI ^［1］。POI在40岁以下女性中的患病率约1%^［2-3］，POI患者仅有5%~10%的自然妊娠率^［4］，是导致育龄女性不孕的常见生殖内分泌疾病。研究表明，部分POI患者卵巢内仍含有残余原始卵泡^［5-6］，这些残余卵泡处于休眠状态，不能被激活并生长发育产生雌孕激素，维持正常的月经周期。由于POI患者残余卵泡数目少且对激素敏感性低^1,7］常规的辅助生殖技术很难帮助POI患者激活残余的原始卵泡，获得具有妊娠能力的高质量卵子^［8］。因此利用捐赠的卵母细胞进行体外受精及胚胎移植仍是治疗POI不孕症的最终方法。

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关键词: 早发性卵巢功能不全卵泡发育体外激活磷脂酰肌醇-3-激酶-丝/苏氨酸蛋白激酶 Hippo信号

收稿日期: 2021-08-20 发布日期: 2022-01-28

基金资助: 国家自然基金面上项目（82071605）；申康临床“五新”创新研发项目重大临床研究项目（SHDC2020CR3054B）

通讯作者: 李文 E-mail: Email：lyyliwen@sina.com

引用本文:

李紫袁　李文. 体外激活治疗早发性卵巢功能不全的研究进展[J]. 发育医学电子杂志, 2022, 10(1): 58-63.
Li Ziyuan, Li Wen. Advances of in vitro activation for premature ovarian insufficiency. Journal of Developmental Medicine(Electronic Version), 2022, 10(1): 58-63.

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http://www.fyyxzz.com/CN/10.3969/j.issn.2095-5340.2022.01.011 或 http://www.fyyxzz.com/CN/Y2022/V10/I1/58

[1]	蒋忠新　李文. 早发性卵巢功能不全的生殖治疗现状与展望[J]. 发育医学电子杂志, 2020, 8(2): 99-105.
[2]	舒晓巍　党小红　刘以训. 1 例多囊卵巢综合征患者在体外受精周期中卵泡发育迟缓的治疗[J]. 发育医学电子杂志, 2018, 6(4): 247-248.

[1]	Society of Neonatologist, Chinese Medical Doctor Association. Consensus recommendations on the prevention and early management of respiratory distress syndrome in preterm infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 129 -131 .
[2]	Professional Committee of Respiratory, Society of Neonatologist, Chinese Medical Doctor Association. Clinical application recommendations for heated humidified high flow nasal cannula[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 132 -135 .
[3]	YAN Jun, ZHU Xing-wang, SHI Yuan. Application progress of noninvasive ventilate technique for premature infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 136 -140 .
[4]	GU Min-fang, YANG Chuan-zhong. Progress of intrapartum resuscitation for premature infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 141 -145 .
[5]	LIU Shu-hua, SHEN Yue-bo, LIU Cui-qing, MA Li. The efficacy of pulmonary surfactant for pulmonary function in premature tension pneumothorax[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 146 -151 .
[6]	GAO Xiao-hui, MAO Jian. Clinical features of non-oliguric hyperkalemia in extremely low birth weight infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 152 -158 .
[7]	XIA Yao-fang, YANG Juan , TIAN Bao-li, et al. Value of amplitude-integrated electroencephalography in monitoring acute period of neonatal bilirubin encephalopathy and prognostic assessment[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 159 -163 .
[8]	WANG Li-rong, SUN Xiao-yan, ZHU Ruo-xin, et al. Epidemiological investigation and analysis of women aged 40-55 years old with osteoporosis in Gansu province[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 164 -167 .
[9]	CHEN Ru-yue, SHEN Yun-yan, CHEN Qing , et al. Five cases about Henoch-Schönlein purpura complicated with central nervous system injury in children and literatures review[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 168 -171 .
[10]	ZHANG Ai-run, FANG Xiao-yi. Lung function testing of bronchopulmonary dysplasia for infants and children[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 172 -176 .

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