发育医学电子杂志 2021, Vol. 9 Issue (1): 76-80 DOI: 10.3969/j.issn.2095-5340.2021.01.014 |
生殖胚胎
综述
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N6- 甲基腺嘌呤在配子发生及胚胎发育中的研究进展
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蒋忠新 李文
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海军军医大学附属长征医院 生殖医学中心,上海 200003
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Reasearch advances of N6-methyladenosine in gametogenesis and embryonic development |
Jiang Zhongxin , Li Wen |
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摘要
表观遗传学对于遗传信息的正确传递十分关键,在生殖发育中扮演着重要角色。RNA 修饰是表观遗传学的重要组成部分,N6- 甲基腺嘌呤(N6-methyladenosine,m6A)则是真核生物 RNA 中含量最为丰富的碱基修饰,且这一修饰具有动态可逆性[1]。其在调控基因表达与蛋白翻译、RNA 相分离与转运、RNA 编辑、可变剪接、稳定性和降解等方面具有多种作用[2-4] 。近年来,m6A 修饰在正常生理过程及病理状态下的研究日渐深入,涉及应激、DNA修复、昼夜节律、干细胞分化、性别决定、造血和肿瘤发生等多种生物过程。m6A 修饰在配子发生与胚胎发育中等生殖过程的作用也逐渐被揭示:参与从配子发生、合子形成到胚胎发育各个阶段的生殖发育过程,具有重要意义。
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关键词:
N6-甲基腺嘌呤')" href="#">
N6-甲基腺嘌呤
RNA甲基化')" href="#">RNA甲基化
配子发生
发育
生殖
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收稿日期: 2020-01-13
发布日期: 2021-01-29
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基金资助:
国家重点研发计划(2018YFC1002802);国家自然科学基金(82071605);宁夏回族自治区重点
研发计划(2019BFG02007)
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通讯作者:
李文
E-mail: liwen@smmu.edu.cn
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