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发育医学电子杂志  2025, Vol. 13 Issue (1): 73-80    DOI: 10.3969/j.issn.2095-5340.2025.01.011
  生长发育   综述 |
儿童抽动障碍与肠道微生物群的关系研究进展
李中原 胡晓红
解放军总医院第四医学中心 儿科, 北京 100048
Research advances in the relationship between tic disorder and gut microbiota in children
Li Zhongyuan, Hu Xiaohong
(Department of Pediatrics, the Fourth Medical Center of Chinese PLA GeneralHospital, Beijing 100048, China)
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摘要 【摘要】 抽动障碍通常在儿童期发病,临床表现包括运动抽动和发声抽动,部分可持续至成年期。抽动
障碍可导致患儿产生社交障碍、身体不适或情绪问题,且常共患注意缺陷多动障碍、强迫障碍等,影响日
常生活和在校表现。截至目前抽动障碍的发病机制尚不完全清楚,肠道微生物群是影响其发病的因素
之一,近年来两者的关系被广泛研究。本文就该领域的研究现状作一综述,并对目前以肠道微生物群为
靶点的干预性研究的进展进行梳理。
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关键词:  抽动障碍  儿童  肠道微生物群  微生物- 肠- 脑轴  粪微生态移植    
Abstract: 【Abstract】Tic disorder usually onset in childhood and are characterized by motor and vocal tics, some of which may persist into adulthood. Tic disorder can lead to social, physical, or emotional problems, and are often associated with attention deficit hyperactivity disorder and obsessive-compulsive disorder, affecting daily life and school performance. The pathogenesis of tic disorder is still not fully understood until now. The relationship between gut microbiota and tic disorder has been widely studied in recent years, as the gut microbiota is one of the factors affecting the pathogenesis of tic disorder. A review of the current state of researches in this area is presented, and the progress of current interventional studies targeting the gut microbiota is summarized.
Key words:  Tic disorder    Children    Gut microbiota    Microbial-gut-brain axis    Fecal microbiotatransplantation
收稿日期:  2024-08-02                     发布日期:  2025-01-26     
通讯作者:  胡晓红    E-mail:  xhh304@163.com
引用本文:    
李中原 胡晓红. 儿童抽动障碍与肠道微生物群的关系研究进展[J]. 发育医学电子杂志, 2025, 13(1): 73-80.
Li Zhongyuan, Hu Xiaohong. Research advances in the relationship between tic disorder and gut microbiota in children. Journal of Developmental Medicine(Electronic Version), 2025, 13(1): 73-80.
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http://www.fyyxzz.com/CN/10.3969/j.issn.2095-5340.2025.01.011  或          http://www.fyyxzz.com/CN/Y2025/V13/I1/73
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