sFlt-1/PLGF 比值在子痫前期中的应用进展

doi:10.3969/j.issn.2095-5340.2025.02.013

发育医学电子杂志

2025, Vol. 13

Issue (2): 154-160 DOI: 10.3969/j.issn.2095-5340.2025.02.013

围产医学综述｜产科

sFlt-1/PLGF 比值在子痫前期中的应用进展

山蕾　周涛　邱娟娟　倪晴　柏婷　彭兰

（1. 温州医科大学附属衢州医院产科，浙江　衢州　324000 ；2. 南京医科大学附属苏州医院　产科，江苏　苏州 215000）

Application progress of sFlt-1/PLGF ratio in preeclampsia

Shan Lei, Zhou Tao, Qiu Juanjuan, et al

(1. Department of Obstetrics, Quzhou Hospital Affiliated to Wenzhou Medical University, Zhejiang, Quzhou 324000, China; 2. Department of Obstetrics, the Affiliated Suzhou Hospital of Nanjing Medical University, Jiangsu, Suzhou 215000, China)

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摘要 【摘要】 子痫前期是导致母婴不良结局甚至死亡的最常见原因之一。可溶性fms 样酪氨酸激酶-1（soluble
fms-like tyrosine kinase-1，sFlt-1）与胎盘生长因子（placental growth factor，PLGF）的比值直接反映了胎
盘合体滋养细胞的失衡状态，有望成为子痫前期预测、辅助诊断和预后的关键生物标志物。本文概述了
sFlt-1/PLGF 比值在子痫前期发病过程和疾病进展中的病理生理作用，并综述了sFlt-1/PLGF 比值在子
痫前期诊断、预测、治疗等方面的临床研究进展。

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关键词: 子痫前期妊娠期高血压疾病血管生成因子胎盘生长因子血管生成

Abstract: 【Abstract】Preeclampsia is one of the most common causes of adverse maternal and neonatal outcomes,even death. The ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PLGF) as a direct indicator of the dysregulation within placental syncytiotrophoblast cells. This ratio is poised to emerge as a pivotal biomarker for the prediction, auxiliary diagnosis, and prognosis of preeclampsia. This article delineates the pathophysiological role of the sFlt-1/PLGF ratio in the etiology and progression of preeclampsia. Furthermore, it offers a comprehensive summary of the clinical research advancements concerning the application of the sFlt-1/PLGF ratio in diagnosing, predicting, and treatment of preeclampsia.

Key words: Preeclampsia Gestational hypertension Angiogenic factor Placental growth factor Angiogenesis

收稿日期: 2024-02-01 发布日期: 2025-03-31

基金资助: 南京医科大学姑苏学院专病队列项目（GSKY20220410）；苏州市医疗卫生科技创新（指令性）项目（SKY2022056）

通讯作者: 彭兰 E-mail: Nannanpeng123@hotmail.com

引用本文:

山蕾　周涛　邱娟娟　倪晴　柏婷　彭兰. sFlt-1/PLGF 比值在子痫前期中的应用进展[J]. 发育医学电子杂志, 2025, 13(2): 154-160.
Shan Lei, Zhou Tao, Qiu Juanjuan, et al. Application progress of sFlt-1/PLGF ratio in preeclampsia. Journal of Developmental Medicine(Electronic Version), 2025, 13(2): 154-160.

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