Mendelian randomization analysis on the causal relationship between systemic lupus erythematosus and preeclampsia
Gui Qi, Hou Wei, Hu Jialin, et al
(1. Chinese PLA Medical School,Beijing 100853, China; 2. Medical of School, Nankai University, Tianjin 300071, China; 3. Department ofObstetrics and Gynecology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853,China; 4. Department of Obstetrics and Gynecology, the Seventh Medical Center of Chinese PLA General Hospital, Beijing 100700, China)
Abstract: 【Abstract】 Objective To investigate the causal relationship between systemic lupus erythematosus (SLE)and preeclampsia (PE). Method Utilizing the R package TwoSampleMR (0.6.4), single nucleotide polymorphism (SNP) significantly associated with SLE were screened from the IEU OpenGWAS database and used as instrumental variables. A dataset containing 7 071 163 SNP for SLE and another with 24 165 538 SNP for PE were obtained. Mendelian randomization (MR) analysis were conducted using inverse-variance weighting (IVW), MR-Egger regression, the weighted median estimator (WME), simple mode (SM), and weighted mode (WM). The causal relationship between SLE and PE was evaluated by calculating odds ratios (OR) and 95% CI. Cochran's Q test for heterogeneity, MR-Egger horizontal pleiotropytest and leave-one-out analysis were performed to assess the stability and reliability of the data. Result Atotal of 42 SNP were included as instrumental variables. The IVW analysis suggested a causal relationshipbetween SLE and the risk of PE (OR=1.038, 95% CI: 1.003-1.073, P<0.05). Consistent results were alsoobtained from the MR-Egger regression analysis (OR=1.094, 95% CI: 1.020-1.174, P<0.05). However, nocausal relationship was found between SLE and PE in the WME, SM, and WM analysis. Cochran's Q test forheterogeneity and MR-Egger horizontal pleiotropy test indicated no heterogeneity or horizontal pleiotropyamong the SNP. The leave-one-out analysis suggested that no single SNP had a significant impact on the overall results. Conclusion MR analysis suggests that SLE may increase the risk of developing PE.
2024, Vol. 12 
