抗生素,盆腔脓肿,细菌潜生体,病理," /> 抗生素,盆腔脓肿,细菌潜生体,病理,"/> Antibiotics, Pelvic abscess, Bacterial cryptozoa,Pathology ,"/> <div> <span style="font-size:14px;line-height:2;">不规范的抗生素治疗盆腔脓肿对细菌</span><span style="font-size:14px;">潜生体的影响研究</span> </div>
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发育医学电子杂志  2021, Vol. 9 Issue (1): 49-54    DOI: 10.3969/j.issn.2095-5340.2021.01.009
  围产医学   论著 |产科 |
不规范的抗生素治疗盆腔脓肿对细菌潜生体的影响研究
何利芳  赵小荣  钟琼  周宏  蔡亚兰
1. 湖北省仙桃市第一人民医院 妇产科,湖北 仙桃 433000;2. 哈尔滨医科大学附属第一医院 妇产科, 黑龙江 哈尔滨 150000
Study on the correlation between non-standard antibiotics and bacterial cryptozoa in pelvic
abscess
He Lifang , Zhao Xiaorong , Zhong Qiong, et al
1.Department of Obstetrics and Gynecolog, Xiantao First People’s Hospital, Hubei, Xiantao 433000, China; 2. Department of Obstetrics and Gynecolog, the First Affiliated Hospital of Harbin Medical University, Heilongjiang, Harbin 150000, China
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摘要 
【摘要】 目的  探讨不规范的抗生素治疗盆腔脓肿对细菌潜生体形成的影响。 方法 于 2017 年 10 月
至 2018 年 6 月选取 SPF 级 SD 雌鼠进行研究,48 只用于建立单纯盆腔炎性疾病大鼠模型,随机分为
8 组,7 组为模型组,1 组为对照组,每组 6 只,模型组仅用刀柄在双侧输卵管系膜处来回刮 3 次,对照组
不予以任何处理。40 只用于建立单纯盆腔炎性疾病急性加重期大鼠模型,随机分为 4 组,1 组为对照组,1 组为手术组、2 组为抗生素组,每组各 10 只,手术组仅用刀柄在双侧输卵管系膜来回刮 3 次,抗生素组
模拟临床不规范的抗生素治疗,制备 1/2 标准治疗浓度的头孢哌酮钠,在单纯盆腔炎性疾病急性发作的
第 4、6、8 天连续给药。分析样本病理结果,镜下观察细菌潜生体的产生。统计学方法采用 χ2t 和 F 检
验。 结果  解剖对照组大鼠后发现,输卵管形状正常,浆膜表面光滑,骨盆内无液体,输卵管和子宫未
附着于周围器官。第 7 ~ 17 天是单纯盆腔炎性疾病的急性发作期。单纯盆腔炎性疾病模型组第 3、5、7、
13、15 天两两比较差异均具有统计学意义(P<0.05),病理结果评分随时间呈现逐渐上升趋势,从第 17 天开始评分下降,第 15 天和第 17 天的病理结果评分比较差异无统计学意义(P>0.05)。 第 30 天评分与第3 ~ 17 天逐一比较差异有统计学意义(P<0.05)。单纯盆腔炎性疾病急性加重期模型组第 13 ~ 17 天时,病理结果评分逐渐升高,与第 13 天相比,第 15 天和第 17 天的病理结果评分明显更高,差异有统计学意义(P<0.05);但第 15 天和第 17 天的病理结果评分比较差异无统计学意义(P>0.05)。组间比较发现,单纯盆腔炎性疾病模型组大鼠第 3 ~ 30 天病理结果评分均低于单纯盆腔炎性疾病急性加重期模型组第
13 ~ 17 天,差异有统计学意义(P<0.05)。 结论 不规范的抗生素治疗是诱导单纯盆腔炎性疾病出现
细菌潜生体的重要因素,并可诱发盆腔脓肿。

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关键词:  抗生素')" href="#">">抗生素  盆腔脓肿  细菌潜生体  病理    
Abstract: 
【Abstract】 Objective To investigate the effect of non-standard antibiotics on the formation of
bacterial cryptozoa in pelvic abscess. Methods From October 2017 to June 2018 SPF SD female rats
were selected for study, 48 cases used to establish the rat model with simple pelvic inflflammatory disease,were randomly divided into eight groups, seven groups for the model groups, one group as the controlgroup, each group of six rats, model group only with the handle in the bilateral mesosalpinx scrapingback and forth three times, the control group not be any processing. 40 cases used to build simple pelvicinflflammatory disease in the rat model with acute aggravating period, randomly divided into four groups,one group to the control group, surgery group, two groups of antibiotics, each group of 10 rats, scores onlywith the handle in bilateral mesosalpinx scraping back and forth three times, simulating clinical antibioticsgroup was not standard antibiotic treatment, the preparation of 1/2 standard treatment concentration ofcefoperazone sodium, in pure day 4 of acute pelvic inflflammatory disease, 6 and 8 days continuous dosing.The pathological results of the samples were analyzed and the production of bacterial cryptic organismswas observed under the microscope. Statistical methods χ2 , t and F tests were used. Results Afterdissecting the rats in the control group, it found that the tubal shape was normal, the serosal surface wassmooth, there was no flfluid in the pelvis, and the tubal and uterus were not attached to the surrounding organs.The outcome of the model of simple pelvic inflflammatory disease showed that the acute stage of simplepelvic inflflammatory disease was from day 7 to day 17. Pure pelvic inflflammatory disease model group 3,5, 7, 13, 15 days pair-wise comparison differences were statistically significant (P<0.05), pathologicalresults score showed a trend of increasing over time, from start scoring on day 17, compared with thepathological results of 15 and 17 days score there was no statistically significant difference (P>0.05).The scores on day 30 were significantly different from those on day 3 to 15 for one by one comparison(P<0.05). In the model group of acute exacerbation of simple pelvic inflflammatory disease, the pathologicalresult score gradually increased from day 13 to day 17. Compared with day 13, the pathological result scoreon day 15 and day 17 was significantly higher, with statistically significant difference (P<0.05). However,there was no statistically significant difference in the pathological result score between day 15 and day 17(P>0.05). Comparison between groups showed that the pathological result scores of rats in the model groupwith simple pelvic inflflammatory disease on the 3rd ~ 30th day were lower than those in the model group withacute exacerbation of simple pelvic inflflammatory disease on the 13th -17th days, with statistically significantdifference (P<0.05). Conclusion Non-standard antibiotic therapy is an important factor in inducing bacterialcryptozoa in pelvic inflflammatory disease, and it can induce pelvic abscess.
Key words: 
收稿日期:  2020-11-13                     发布日期:  2021-01-28     
基金资助: 
湖北省自然科学基金(2019CFB610)
通讯作者:  蔡亚兰    E-mail:  185304552@qq.com
引用本文:    
何利芳  赵小荣  钟琼  周宏  蔡亚兰.
不规范的抗生素治疗盆腔脓肿对细菌潜生体的影响研究
[J]. 发育医学电子杂志, 2021, 9(1): 49-54.
He Lifang , Zhao Xiaorong , Zhong Qiong, et al.
Study on the correlation between non-standard antibiotics and bacterial cryptozoa in pelvic
abscess
. Journal of Developmental Medicine(Electronic Version), 2021, 9(1): 49-54.
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