Study on the correlation between non-standard antibiotics and bacterial cryptozoa in pelvic
abscess
He Lifang , Zhao Xiaorong , Zhong Qiong, et al
1.Department of Obstetrics and Gynecolog, Xiantao First People’s Hospital, Hubei, Xiantao 433000, China; 2. Department of Obstetrics and Gynecolog, the First Affiliated Hospital of Harbin Medical University, Heilongjiang, Harbin 150000, China
【Abstract】 Objective To investigate the effect of non-standard antibiotics on the formation of
bacterial cryptozoa in pelvic abscess. Methods From October 2017 to June 2018 SPF SD female rats
were selected for study, 48 cases used to establish the rat model with simple pelvic inflflammatory disease,were randomly divided into eight groups, seven groups for the model groups, one group as the controlgroup, each group of six rats, model group only with the handle in the bilateral mesosalpinx scrapingback and forth three times, the control group not be any processing. 40 cases used to build simple pelvicinflflammatory disease in the rat model with acute aggravating period, randomly divided into four groups,one group to the control group, surgery group, two groups of antibiotics, each group of 10 rats, scores onlywith the handle in bilateral mesosalpinx scraping back and forth three times, simulating clinical antibioticsgroup was not standard antibiotic treatment, the preparation of 1/2 standard treatment concentration ofcefoperazone sodium, in pure day 4 of acute pelvic inflflammatory disease, 6 and 8 days continuous dosing.The pathological results of the samples were analyzed and the production of bacterial cryptic organismswas observed under the microscope. Statistical methods χ2 , t and F tests were used. Results Afterdissecting the rats in the control group, it found that the tubal shape was normal, the serosal surface wassmooth, there was no flfluid in the pelvis, and the tubal and uterus were not attached to the surrounding organs.The outcome of the model of simple pelvic inflflammatory disease showed that the acute stage of simplepelvic inflflammatory disease was from day 7 to day 17. Pure pelvic inflflammatory disease model group 3,5, 7, 13, 15 days pair-wise comparison differences were statistically significant (P<0.05), pathologicalresults score showed a trend of increasing over time, from start scoring on day 17, compared with thepathological results of 15 and 17 days score there was no statistically significant difference (P>0.05).The scores on day 30 were significantly different from those on day 3 to 15 for one by one comparison(P<0.05). In the model group of acute exacerbation of simple pelvic inflflammatory disease, the pathologicalresult score gradually increased from day 13 to day 17. Compared with day 13, the pathological result scoreon day 15 and day 17 was significantly higher, with statistically significant difference (P<0.05). However,there was no statistically significant difference in the pathological result score between day 15 and day 17(P>0.05). Comparison between groups showed that the pathological result scores of rats in the model groupwith simple pelvic inflflammatory disease on the 3rd ~ 30th day were lower than those in the model group withacute exacerbation of simple pelvic inflflammatory disease on the 13th -17th days, with statistically significantdifference (P<0.05). Conclusion Non-standard antibiotic therapy is an important factor in inducing bacterialcryptozoa in pelvic inflflammatory disease, and it can induce pelvic abscess.
2021, Vol. 9 
