Value of serum endothelial cell specific molecular-1 and heparin-binding protein in theprognostic evaluation of Mycoplasma pneumoniae infection in children
Li Jia , Xu Dan, Liu Yu, et al.
1. Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; 2. Department of the Third Surgery, Hengshui Second People's Hospital, Hengshui, Hebei 053000, China
Objective To explore the value of serum endothelial cell specific molecule-1 (ESM-1) and heparin binding protein (HBP) in prognostic evaluation of Mycoplasma pneumoniae (MP) infection in children. Methods A prospective study was conducted. A total of 168 children with MP admitted to Beijing Friendship Hospital, Capital Medical University from January 2022 to January 2023 were enrolled as the MP group. Based on treatment outcomes, they were divided into the favorable prognosis group (n=112) and the poor prognosis group (n=56). During the same period, 150 healthy children who underwent physical examinations at the hospital were selected as the control group by using a random number table method. The general data including age and body mass index were recorded for all participants. The expression levels of serum ESM-1 and HBP were detected using enzyme-linked immunosorbent assay (ELISA). Multivariate Logistic regression analysis was performed to explore the influencing factors of poor prognosis in children with MP
infection. Pearson method was used to evaluate the correlation between serum ESM-1 and HBP expression levels in children with poor prognosis. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic value of serum ESM-1 and HBP expression levels for poor prognosis in children with MP infection, and the Delong test was applied to compare the differences in the area under the curve (AUC). Statistical analysis was performed using the independent sample t-test and χ2 test. Results The serum expression levels of ESM-1 and HBP in the MP group were significantly higher than those in the control group［(4.81±1.42) μg/L vs (3.69±1.13) μg/L, (24.47±7.31) μg/L vs (18.74±6.11) μg/L, t values were 7.720, 7.534, all P<0.001］. The serum expression levels of high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), ESM-1, and HBP in the poor prognosis group were significantly higher than those in the favorable prognosis group［(25.34±7.56) mg/L vs (21.28±6.32) mg/L, (8.66±2.61) μg/L vs (6.21±1.93) μg/L, (345.72±103.25) U/L vs (267.21±83.14) U/L, (5.78±1.56) μg/L vs (4.32±1.14) μg/L, (29.16±7.11) μg/L vs(22.13±6.24) μg/L, t values were 3.672, 6.870, 5.312, 6.892, 6.567, all P<0.001］. Multivariate Logistic regression analysis showed that the serum expression levels of hs-CRP, ESM-1, and HBP were independent risk factors for poor prognosis in children with MP (OR values were 1.546, 1.587, 1.826, respectively, all P<0.05). Pearson correlation analysis showed that the serum expression levels of ESM-1 was positively correlated with HBP in children with poor prognosi, (r=0.445, P<0.001). ROC curve analysis showed that the AUC values for ESM-1 alone, HBP alone, and their combination in predicting poor prognosis in children with MP was 0.791, 0.820, and 0.880, respectively. The combined diagnosis of ESM-1 and HBP was superior to either ESM-1 alone or HBP alone (Z values were 2.889, 2.084, respectively, all P<0.05). Conclusion Serum ESM-1 and HBP have high value in prognosis evaluation of MP children, and can be used as effective indicators for early diagnosis and prognosis evaluation.
[J]. 发育医学电子杂志, 2026, 14(3): 216-222.
Li Jia , Xu Dan, Liu Yu, et al..
Value of serum endothelial cell specific molecular-1 and heparin-binding protein in theprognostic evaluation of Mycoplasma pneumoniae infection in children
. Journal of Developmental Medicine(Electronic Version), 2026, 14(3): 216-222.
2026, Vol. 14 
