Clinical data and prognosis analysis of 18 full-term neonates with cerebral infarction
Mei Yabo, Zhang Na, Li Qiuping, et al
BaYi Children’s Hospital, Seventh Medical Centerof Chinese PLA General Hospital; Department of Pediatrics, Chinese PLA General Hospital; NationalEngineering Laboratory for Birth defects prevention and control of key technology; Beijing Key Laboratoryof Pediatric Organ Failure, Beijing 100700, China
【Abstract】 Objective To investigate the possible etiology, clinical features, and prognosis of cerebral
infarction in full-term neonates. Methods To retrospectively analyze the clinical data of 18 full-term
neonates with neonatal cerebral infarction (NCI) admitted to NICU of the Seventh Medical Center of
PLA General Hospital from June 2008 to June 2018, and analyze the perinatal high-risk factors, clinical
manifestations, imaging features and follow-up results of 15 infants. Results None of the 18 neonateswith NCI had a clear history of resuscitation. Four neonates had a history of intrauterine distress and 3 ofwhich belonging to amniotic flfluid type (severe meconium stained amniotic flfluid). Thirteen neonates (72.2%)were the baby of first production. Convulsion was the main clinical manifestation(16/18, 88.9%), and the timeof convulsion was mainly concentrated at 72 hours after birth (16/18, 88.9%). The median time of symptomonset in all 18 neonates was 24 h. The diagnosis was according to MRI/CT scan and clinical manifestations.MRI/CT scans showed that 10 cases (55.6%) of cerebral infarction involved the left cerebral hemisphere.Three infants were discontinued due to parental factors and were eventually lost to follow-up. None of theremaining 15 infants had intellectual developmental disorder, 5 infants of which had motor development
disorder(1 infant had motor defects, language disorder and epilepsy, and one infant combined with motor
defects of language disorder). Conclusions The etiology of NCI is complex, and with no definitive factor.
Convulsion is the most common clinical manifestation, most of which develop shortly after birth. NCI can
cause long-term motor defect, language development disorder of which, seizure may occur in a small number.
2020, Vol. 8 
