Research progress on gut microbiota and pediatric non-alcoholic fatty liver disease
Peng Xiaoning, Chen Dehong, Shi Chunhua, et al
Department of Pediatric Gastroenterology and Endocrinology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250000, China
In recent years, the proportion of non-alcoholic fatty liver disease (NAFLD) among liver diseases in children has been increasing year by year. The pathogenesis of NAFLD has not been fully clarified. Numerous studies have indicated that alterations in the gut microbiota are associated with the occurrence and development of NAFLD. Its metabolites may give rise to insulin resistance or low-grade inflammation, thereby resulting in the disease. This also hints that improving gut microbiota dysbiosis might be a potential target for the treatment of NAFLD. This article presents a review of the possible mechanisms by which the gut microbiota and its metabolites cause the disease and elaborates on the relevant research progress in the treatment of NAFLD through methods of regulating the gut microbiota, providing new directions and ideas for disease treatment.
2026, Vol. 14 
