发育医学电子杂志 2023, Vol. 11 Issue (2): 141-147 DOI: 10.3969/j.issn.2095-5340.2023.02.010
生殖胚胎
综述
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氧化应激与男性不育症相关性研究进展
李宇翔 谭扬扬 张大伟 袁亚成 李瑞杰 邱小龙 罗恒丰 杨旭凯
(1. 甘肃中医药大学第一临床医学院 泌尿外科,甘肃 兰州 730000 ;2. 解放军联 勤保障部队第940 医院 泌尿外科,甘肃 兰州 730050 ;3. 甘肃省干细胞与基因 药物重点实验室,甘肃 兰州 730050)
Research progress on the correlation between oxidative stress and male infertility
Li Yuxiang, Tan Yangyang, Zhang Dawei, et al
摘要 男性不育症定义为由男性因素导致育龄夫妻 在无保护措施维持性生活1 年后仍然无法自然怀 孕。全球约有15% 的夫妇经历不孕不育症困扰[1] , 其中约一半的不孕不育取决于男性因素[2] ,并且 随着社会发展,人类生活方式的改变使得这个比例 逐年增高。活性氧(reactive oxygen species,ROS) 是一类具有高氧化活性的基团,包括超氧阴离子 (O2?-)、过氧化氢(H2O2)、过氧阴离子(ROO?-)、羟基 (OH?)自由基,以及ROS 的另一个子集——活性氮 (reactive nitrogen species,RNS),其中包含具有生 物活性的一氧化氮及与一氧化氮反应形成过氧化 物亚硝酸盐(ONOO-)[3] 。研究表明,在30%~80% 的不育男性中,ROS 介导的精子损伤是导致不育 的主要病理因素[4]
关键词:
氧化应激
活性氧自由基
男性不育
收稿日期: 2022-09-22
出版日期: 2023-03-31
发布日期: 2023-03-31
期的出版日期: 2023-03-31
基金资助: 甘肃省自然科学基金(18JR3RA405、21JR11RA008);兰州市人才创新创业项目(2021-RC-106)
通讯作者:
杨旭凯
E-mail: yangxk125@126.com
[1]
Society of Neonatologist, Chinese Medical Doctor Association. Consensus recommendations on the prevention and early management of respiratory distress syndrome in preterm infants [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 129
-131
.
[2]
Professional Committee of Respiratory, Society of Neonatologist, Chinese Medical Doctor Association. Clinical application recommendations for heated humidified high flow nasal cannula [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 132
-135
.
[3]
YAN Jun, ZHU Xing-wang, SHI Yuan. Application progress of noninvasive ventilate technique for premature infants [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 136
-140
.
[4]
GU Min-fang, YANG Chuan-zhong. Progress of intrapartum resuscitation for premature infants [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 141
-145
.
[5]
LIU Shu-hua, SHEN Yue-bo, LIU Cui-qing, MA Li. The efficacy of pulmonary surfactant for pulmonary function in premature tension pneumothorax [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 146
-151
.
[6]
GAO Xiao-hui, MAO Jian. Clinical features of non-oliguric hyperkalemia in extremely low birth weight infants [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 152
-158
.
[7]
XIA Yao-fang, YANG Juan , TIAN Bao-li, et al. Value of amplitude-integrated electroencephalography in monitoring acute period of neonatal bilirubin encephalopathy and prognostic assessment [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 159
-163
.
[8]
WANG Li-rong, SUN Xiao-yan, ZHU Ruo-xin, et al. Epidemiological investigation and analysis of women aged 40-55 years old with osteoporosis in Gansu province [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 164
-167
.
[9]
CHEN Ru-yue, SHEN Yun-yan, CHEN Qing , et al. Five cases about Henoch-Schönlein purpura complicated with central nervous system injury in children and literatures review [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 168
-171
.
[10]
ZHANG Ai-run, FANG Xiao-yi. Lung function testing of bronchopulmonary dysplasia for infants and children [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 172
-176
.
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