发育医学电子杂志 2023, Vol. 11 Issue (2): 148-153,160 DOI: 10.3969/j.issn.2095-5340.2023.02.011
结构畸形
综述
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肝移植术后感染的危险因素研究进展
黄毓凯 刘雪来
(1. 厦门医学院 临床医学系,福建 厦门 361023; 2. 首都 儿科研究所附属儿童医院 外科,北京 100020)
Research progress on risk factors of infection after liver transplantationy
Huang Yukai, Liu Xuelai
摘要 1 9 6 3 年, S t a r z l 教授将肝移植( l i v e r transplantation,LT)技术首次应用于临床。历经 40余年的发展,外科手术技术日趋成熟,已成为 治疗急、慢性肝功能衰竭,肝良性、恶性肿瘤以 及某些代谢性肝病的有效手段[1] 。虽然肝移植在 许多情况下可以挽救生命,但移植受者发生感染 是导致术后死亡的最常见原因[2] 。随着新型免疫 抑制剂的使用,移植手术后的病死率已降至5% 下,受体术后1年生存率接近90%,5年生存率超过 70%[3-4] 。但由于接受移植后的免疫状态和手术相 关的操作技术等因素,术后感染仍然是导致移植 物功能障碍和患者死亡的主要原因之一 [5] 。
关键词:
肝移植
感染
Toll样受体
收稿日期: 2022-05-06
出版日期: 2023-03-31
发布日期: 2023-03-31
期的出版日期: 2023-03-31
基金资助: 北京市自然科学基金(7222015)
通讯作者:
刘雪来
E-mail: liuxuelai_steven@163.com
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