发育医学电子杂志 2021, Vol. 9 Issue (2): 81-86 DOI: 10.3969/j.issn.2095-5340.2021.02.001
生殖胚胎
专题笔谈
|
卵巢储备功能的影响因素及评估方法 #br#
康诠敏 金帆
(浙江大学医学院附属妇产科医院 生殖内分泌科,浙江 杭州 310000 )
Evaluation methods and influencing factors of ovarian reserve function
Kang Quanmin Jin Fan#br#
摘要 卵巢储备指的是女性卵巢内卵泡的数量及卵 母细胞的质量,反映女性生育潜能[1] 。临床上把卵
巢内卵泡数量减少、发育异常或卵子质量降低统称 为卵巢低储备(diminished ovarian reserve,DOR)。
与月经周期正常的同龄女性相比,患有DOR 的女 性常表现为:卵泡消耗异常,体外受精- 胚胎移植
(in vitro fertilization-embryo transfer,IVF-ET)周期 中卵巢对促性腺激素低敏,伴有激素紊乱和生育力
减退,最终导致不良妊娠结局 [1] 。辅助生殖技术 (assistant reproductive technology,ART)是不孕症的
主要治疗手段,在寻求ART 治疗的不孕症女性中, DOR 患者占10%[2] 。2015 年美国生殖医学学会提
出,目前DOR 的定义并不明确,不同于绝经过渡期 和卵巢早衰(premature ovarian failure,POF),DOR
与3 种临床结局相关:卵母细胞的数量、卵母细胞 的质量和女性生育潜能。
关键词:
">体外受精- 胚胎移植')" href="#">">体外受精- 胚胎移植
 
">卵巢低储备')" href="#">">卵巢低储备
line-height:2
卵巢早衰')" href="#">">卵巢早衰
收稿日期: 2020-11-04
发布日期: 2021-04-01
基金资助: 国家重点研发计划(2018YFC1004902)
通讯作者:
金帆
E-mail: Email:jinfan@zju.edu.cn
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