Abstract: 【Abstract】 Objective To explore the value of neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH), and interleukin-6 (IL-6) levels in prognostic assessment of children with Mycoplasmapneumoniae pneumonia (MPP). Method A total of 180 children with MPP admitted to KunmingChildren's Hospital from September 2020 to February 2021 were selected as the observation group byprospective studies, including 104 ordinary children and 76 severe children, and 60 healthy children whounderwent physical examination during the same period were selected as the control group. The levels ofNLR, LDH, and IL-6 were compared between the observation group and the control group to evaluate theevaluation value of NLR, LDH, and IL-6 for the severity of MPP in children. According to the prognosisof MPP, the children with MMP were divided into poor prognosis group (n=35) and good prognosis group(n=145). The clinical data, NLR, LDH, and IL-6 levels of MMP children with different prognoses werecompared, and the prognostic factors of MPP in children and the correlation between NLR, LDH, IL-6 andClinical Pulmonary Infection Score (CPIS), white blood cell count (WBC), procalcitonim (PCT), C-reactiveprotein (CRP) were analyzed. Statistical methods performed by t-test, χ2 test, Logistic regression analysis, receiveroperating characteristic (ROC) curve analysis and Spearman model analysis. Result The NLR of ordinary andsevere children in the observation group and the control group were 1.5±0.3, 2.2±0.3 and 1.2±0.2, respectively,and the levels of LDH were (439.8±30.1) U/L, (528.6±35.6) U/L and (125.8±28.9) U/L, respectively, the levelsof IL-6 were (18.3±1.3) ng/L, (25.8±2.1) ng/L and (9.5±1.2) ng/L, respectively, and the NLR, LDH, andIL-6 levels in the observation group were higher than those in the control group (NLR: t=10.135, 27.514,LDH: t=86.323, 103.974, IL-6: t=44.834, 84.297, all P<0.05), and the NLR, LDH, and IL-6 levels in theordinary children of observation group were lower than those in the severe children (NLR: t=20.599, LDH:t=26.252, IL-6: t=48.065, all P<0.05). The area under the curve (AUC) of the combined assessment ofNLR, LDH, and IL-6 was the highest, at 0.911, with the sensitivity and specificity of 82.89% and 89.42%,respectively. The CPIS (OR=7.232, 95% CI: 5.055-10.347), WBC (OR=6.839, 95% CI: 4.752-9.844), PCT(OR=8.882, 95% CI: 6.375-12.374), CRP (OR=11.520, 95% CI: 8.125-16.333), NLR (OR=11.517, 95% CI:7.852-16.894), LDH (OR=11.881, 95% CI: 7.698-18.337), and IL-6 (OR=12.424, 95% CI: 8.025-19.235)were the independent risk factors for the prognosis of MPP childrenin (all P<0.05). The levels of NLR, LDHand IL-6 in children with MPP were positively correlated with CPIS, WBC, PCT and CRP (all P<0.05). Conclusion The levels of NLR, LDH and IL-6 in children with MPP are significantly increased, which canbe used as potential indicators for evaluating the condition and prognosis of MPP.
吴玉芹 黄荣卫 刘兴祝 杨燕飞 王智海. NLR、LDH、IL-6 在肺炎支原体肺炎患儿病情及预后评估中的价值[J]. 发育医学电子杂志, 2024, 12(4): 278-283.
Wu Yuqin, Huang Rongwei, Liu Xingzhu, et al. Value of NLR, LDH and IL-6 in the assessment of disease condition and prognosis of childrenwith Mycoplasma pneumoniae pneumonia. Journal of Developmental Medicine(Electronic Version), 2024, 12(4): 278-283.
2024, Vol. 12 
