Abstract: Objective To study the difference in blood glucose control for patients with Type 2 Diabetes（T2D) between perimenopausal stage and early stage of menopause, and to explore the effect of menopausal status on blood glucose control. Methods From June 2013 to May 2016, in The First Hospital of Lanzhou University, 802 hospitalized women aged 45-64 years old with T2D were included. According to the age, they were divided into the perimenopausal group (45-54 years old, 362 cases) and the early stage of menopause group (55-64 years old, 440 cases). Retrospective observational study method was used. The general conditions, level of sex hormone and indications of blood glucose control were compared between the two groups. Independent sample t-test and χ2 test were used for statistical analysis. Results In the perimenopausal group and the early stage of menopause group, course of T2D was (6.2±5.0) vs (7.6±5.5) years and the proportion of hypertension was 40.9% vs 54.3%, which were higher in the early stage of menopause group (all P﹤0.05). 37 patients in the perimenopausal group and 28 patients in the early stage of menopause group detected the level of sex hormone. The estradiol level was (99.5±39.0) vs (41.7±27.2) pmol/L, which was higher in the perimenopausal group. The level of follicle-stimulating hormone was (30.5±22.3) vs (45.4±24.8) U/L, and the level of luteinizing hormone was (17.7±13.1) vs (29.8±11.2) U/L, which was higher in the early stage of menopause group (P﹤0.01). Fasting blood glucose of the perimenopausal group was higher than that of the early stage of menopause group ［(10.0±3.8) vs (8.9±3.6) mmol/L,P﹤0.01］. The utilization rate of insulin secretion was 30.4% vs 22.5% and that of metformin was 83.7 % vs 77.5 % in perimenopausal group and early stage of menopause group respectively, which were both higher in the perimenopausal group (both P﹤0.05). The utilization rate of α-glycosidase inhibitor was 48.9% vs 59.1%, which was higher in the early stage of menopause group (P﹤0.01). There was no difference in the glycosylated hemoglobin, insulin usage rate, hospital stay and hospital costs between the two groups (P﹥0.05). Conclusions The level of fasting blood glucose in the perimenopausal women with T2D is higher than that in the early stage of menopause. The blood glucose is more difficult to control in the perimenopausal women.
孙小燕 杨霞 朱若昕 张宝丽 张学红. 女性绝经状态对2型糖尿病患者血糖控制的影响[J]. 发育医学电子杂志, 2017, 5(2): 73-77.
SUN Xiao-yan, YANG Xia, ZHU Ruo-xin, ZHANG Bao-li, ZHANG Xue-hong . Effect of menopausal status on blood glucose control for patients with Type 2 Diabetes. Journal of Developmental Medicine(Electronic Version), 2017, 5(2): 73-77.
2017, Vol. 5 
