发育医学电子杂志  2015, Vol. 3 Issue (2): 65-67 |
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生殖胚胎
专题笔谈
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| 卵巢早衰的激素替代治疗 |
| 陶敏芳 |
| 陶敏芳（上海交通大学附属第六人民医院 妇产科，上海 200030） |
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| The hormone replacement therapy of premature ovarian failure |
| TAO Min-fang |
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摘要 卵巢早衰（premature ovarian failure）是指女性在40岁之前出现闭经、雌激素缺乏、促性腺激素水平升高等卵巢功能衰竭所导致现象。最早是Moraes-Reuhsen等［1］于1967年首先提出的。据此定义，临床诊断提出必须符合以下3点：①年龄< 40岁； ②闭经时间≥6个月； ③ 两次（间隔1个月以上）血卵泡刺激素（follicle-stimulating hormone，FSH）> 40 IU/L。该定义长期以来一直用于临床。随着临床对该现象的重视，发现除医源性以外的卵巢功能衰竭，绝大部分都是渐进性的，即首先出现卵巢功能下降，经过数年以后逐渐衰竭。而卵巢早衰实际上是卵巢功能不全的终末状态。从临床的角度为了能够更加合理临床认定和处理，近年来有学者建议将此现象定义为原发性卵巢功能不全（primary ovarian insufficiency, POI），以强调卵巢衰竭前的过程。而实际上在Moraes-Reuhsen提出卵巢早衰后一年已有学者将此定义提出［2］，只是一直没有被临床采纳。从临床诊断标准来说，与原来的卵巢早衰诊断标准相比只是在月经的变化上放松了标准，即: ①40岁以下的妇女。②持续4个月闭经或月经稀发。③两次FSH>40 IU/L（测定间隔超过1个月）。
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| 关键词:
卵巢早衰 ')" href="#">卵巢早衰
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雌激素
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孕激素
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收稿日期: 2015-01-14
出版日期: 2015-04-30
发布日期: 2018-05-16
期的出版日期: 2015-04-30
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