发育医学电子杂志 2020, Vol. 8 Issue (3): 282-285 DOI: 10.3969/j.issn.2095-5340.2020.03.017 |
围产医学
综述
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母亲肠道微生物向胎儿肠道传播的研究进展
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齐宸 管滔 武晓旭 关怀
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解放军联勤保障部队第九六七医院 妇产科,辽宁 大连 116021
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Progress in the transmission of gut microbiota from mothers to fetuses
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Qi Chen, Guan Tao, Wu Xiaoxu, et al
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摘要
自 20 世纪 20 年代起,人们认为胎儿是无菌的,出生时微生物才开始在其体内定居,分娩方式是影响微生物定植的重要因素[1-3] 。胎盘被认为是天然屏障,能够阻止母体毒素和微生物入侵胎儿,以保证胎儿无菌,确保胎儿正常发育[4-5] 。近十余年,二代测序技术兴起,业已证实微生物普遍存在于人体表面和内部,即便在传统上被视为“无菌”的身体孔洞也不例外,这同样适用于胎儿的生长环境——子宫[6-8] 。国内外学者相继发现,正常妊娠的胎盘、羊水、脐血和胎粪中均有微生物存在[9-13];微生物不仅在出生前定植胎儿,而且可能在胎儿的生长发育中发挥作用[14] 。母亲肠道微生物群可能是胎儿肠道菌群的主要来源。本文对母亲肠道微生物群向胎儿肠道传播的研究进展进行综述。
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关键词:
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微生物">微生物font-size:14px
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肠道font-size:14px
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传播
母亲
胎儿
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收稿日期: 2019-05-10
出版日期: 2020-07-30
发布日期: 2020-07-28
期的出版日期: 2020-07-30
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基金资助:
辽宁省自然科学基金(20180550166、20170540904);辽宁省大连市医学科学研究计划(1712051)
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通讯作者:
关怀
E-mail: 826163030@qq.com
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