Abstract: Objective To investigate the type and prognosis of ventricular septal defect in neonates. Methods From July 2010 to January 2014, 2 023 newborns in Maternal and Child Health Care Hospital, Xicheng District, Beijing were screened at 0-7 days after birth. 46 cases of ventricular septal defect were found, and 2 cases were found at 3 months after birth. The patients were followed up trimonthly to 1-4 years old. The statistical analysis was carried out by χ2 test. Results 8 cases of fetal ventricular septal defect were detected in prenatal period. Among the 8 cases, 1 cases underwent induced labor; 3 cases did not ?nd defects after birth; and 4 cases had ventricular septal defect after birth. There were 42 cases of ventricular septal defect to be found in other neonates on 0-7 days. 2 cases were found when followed up at 3 months after birth. In the 48 children, 37 cases were muscular ventricular septal defect (77.1%, 37/48), 10 cases were membranous part (20.8%, 10/48), and 1 case was supracristal ventricular septal defects (2.1%, 1/48). One case lost follow-up, 39 cases (83%, 39/47) were naturally closed, 5 cases (10.6%, 5/41) were operated, 2 cases (4.3%, 2/47) were not closed, one case (2.1%, 1/47) died. The rate of spontaneous closure of muscular ventricular septal defect was higher than that of membranous ［94.4% (34/36) vs 50% (5/10), χ2=5.773, P ﹤ 0.05］. The rate of spontaneous closure of the defect less than 5 mm group was higher than that of the defect more than 5 mm group ［90.2% (37/41) vs 33.3% (2/6), χ2=5.695, P ﹤ 0.05］, and the operation rate was lower than that of the defect more than 5 mm group ［4.88% (2/41) and 50% (3/6), χ2=4.857，P ﹤ 0.05］. Conclusion The spontaneous closure rate of muscular and small ventricularseptal defect is high, and that of membranous and large ventricular septal defect is low. We should pay attention to follow up and operating time.
2018, Vol. 6 
