Abstract: 【Abstract】 Objective To compare the components of coagulation fibrinolytic system in newborns of different gestational age and different weight, and to provide reference for the clinical significance of coagulation function index. Methods One hundred and seventy cases of newborns (gestational age 28-42 weeks, within 8 h after birth, 87 males, 83 females ) hospitalized in The Fifth Medical Center of PLA General Hospital from January 2015 to December 2018 were divided into three groups according to gestationalage: early preterm neonates group (28-33+6 weeks), late preterm neonates group (34-36+6 weeks), full-termneonates group (37-42 weeks). According to birth weight, they were divided into normal weight group (2 500 g ≤ birth weight<4 000 g), low birth weight group (1 500 g ≤ birth weight<2 500 g) , and verylow birth weight group (<1 500 g). According to the gestational age, they were divided into preterminfants suitable for gestational age group, preterm infants small for gestational age group, term infants suitable for gestational age group and term infants small for gestational age group. The activated partialthromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), the level of fibrinogen (FIB) and D-dimer in neonates were detected within 24 h after birth. Results The level of APTT, PT and D-dimer in early preterm neonate group was higher than that in the late preterm neonates group and fullterm neonates group (all P<0.05) , and the level of FIB in early preterm neonate group was lower than that in the late preterm neonates group and full-term neonates group (all P<0.05) . The level of APTT, PT in the late preterm neonates group was higher than that in the full-term neonates group (all P<0.05), but therewere no significant differences in the level of D-dimer and FIB between the two groups (P>0.05). The level of APTT, PT and D-dimer in very low birth weight group was higher than that in low birth weight group and normal weight group (all P<0.05), and the level of FIB in very low birth weight group was lower than that in the low birth weight group and normal weight group (all P<0.05). The level of APTT, PT in low birth weight group was higher than that in normal weight group (all P<0.05), but there were no significant differences in D-dimer and FIB between the two groups(all P>0.05). The level of D-dimer in preterminfants small for gestational age group was higher than that in preterm infants suitable for gestational age group (P<0.05), and there were no significant differences about other coagulation indexes (all P>0.05). There were no significant differences in blood coagulation indexes between term infants suitable for gestational age group and term infants small for gestational age group (P>0.05). The incidence of bleeding in premature infants was higher than that in term infants [26.6% (29/109) vs 8.2% (5/61), χ2=9.019,P=0.003]. Conclusions The coagulation indexes of neonates showed difference in different gestational age and birth weight. The smaller for gestational age and the lower for birth weight, the more imperfect the coagulation function is.
2020, Vol. 8 
