WU Zhi-xin ,GUO Jie,XU Jing,WU Rong,HUA Shao-dong,FENG Zhi-chun (1.Department of NICU,Bayi Children's Hospital Affiliated to Military General Hospital of Beijing PLA, Beijing 100007; 2.the Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital, Nanning 530005; 3. Department of Pediatrics, HuaiAn Maternal and Child Health-Care Center, Yangzhou University, Jiangsu Huaian 223022;4. Department of Pediatrics, Children's Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215003,China)
Abstract: Objective To study the effect of non-infectious factors on serum procalcitonin(PCT) in preterm neonates. Method The premature infants of neonatal intensive care unit(NICU) in our hospital were chosen from gestational age ranged from 33 to 36 weeks, birth time less than 12 hours without premature rupture and hospitalization period from January 2012 to December 2012. All of the premature infants were drawn blood immediately admitted to hospital and C-reactive protein (CRP), blood cultures and procalcitonin were tested. The types of premature infants non-infectious diseases included intracranial hemorrhage (ICH), neonatal respiratory distress syndrome (NRDS), neonatal asphyxia and the control group (preterm infants)without disease. The blood routine , C-reactive protein, blood culture, procalcitonin and other infections
indicators in each group were monitored dynamicly in order to study the impact of these non-infectious diseases on serum procalcitonin concentrations by statistical analysis. Results ① Compared with the current literature recommended serum procalcitonin concentrations (<0.5ng / ml), procalcitonin concentrations in preterm neonates singnificantly increase (1.07 ± 0.76) ng / ml.②Compared with control group (1.07±0.76) ng/ml,the procalcitonin levels in intracranial hemorrhage group (2.12 ± 0.99) ng/ml, neonatal respiratory distress syndrome group (2.28±1.09) ng/ml and asphyxia group (3.64 ± 3.17) ng / ml significantly increased (F= 10.462, P <0.05).There were no significant differences (F= 0.173, P= 0.950) among the different levels of intracranial hemorrhage group; Compared with the first grade NRDS , the procalcitonin leves in second
grade and third grade NRDS groups were significantly increased (F=5.475, P= 0.010); The procalciton level in severe asphyxia group was significantly higher than in mild asphyxia group (t= 5.245, P= 0.003). Conclusions The procalcitonin concentration physiologically increased after preterm neonates were born.Many factors such as intracranial hemorrhage, neonatal respiratory distress syndrome and neonatal asphyxia can increase procalcitonin concentration so the level of PCT levels can not evaluate accurately preterm children infection.
2015, Vol. 3 
