发育医学电子杂志 2021, Vol. 9 Issue (2): 151-155 DOI: 10.3969/j.issn.2095-5340.2021.02.013
围产医学
综述
|新生儿
|
绒毛膜羊膜炎与早产儿不良结局的 研究进展
方欣 鲁元元 赵小林 张莉 李占魁
(1. 西安医学院 研究生处,陕西 西安 710068;2. 西北妇女儿童医院 新生儿科,陕西 西安 710061)
Research progress of chorioamnionitis and adverse outcomes in preterm infants
Fangxin, Lu Yuanyuan, Zhao Xiaolin, et al
摘要 绒毛膜羊膜炎(chorioamnionitis,CAM)是指病 原微生物进入羊膜腔后引起羊水、胎盘或胎儿的感
染,是早产常见的原因,可能会导致不良新生儿结 局[1-3] 。根据是否有临床表现和胎盘病理结果分为
临床绒毛膜羊膜炎和组织学绒毛膜羊膜炎,其发生 比例约为1 ∶ 9[4] 。主要常见致病菌包括解脲脲原
体、支原体、B 族链球菌和葡萄球菌、阴道加德纳菌、 大肠杆菌、乳杆菌及念珠菌等[5-8] ,它们在感染基础 上引起的免疫反应可使胎儿体内产生多种促炎因 子,最终导致早产的发生;而其导致的炎症反应,也
可能使胎儿许多器官受到影响,从而使早产儿发生 许多严重并发症。研究报道CAM 可能与新生儿呼
吸窘迫综合征、支气管肺发育不良、新生儿早发型 败血症、新生儿坏死性小肠结肠炎、早产儿视网膜 病、早产儿脑损伤等有关[8] 。
关键词:
绒毛膜羊膜炎')" href="#">
绒毛膜羊膜炎
早产
不良结局
发布日期: 2021-04-01
基金资助: 广州市合生元营养与护理研究院“母婴临床研究专项基金”(2019BINCLC007)
通讯作者:
李占魁
E-mail: lzk5808@163.com
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