不同剂量米非司酮治疗子宫内膜异位症的疗效和安全性分析

发育医学电子杂志

2015, Vol. 3

Issue (4): 229-232

结构畸形论著

不同剂量米非司酮治疗子宫内膜异位症的疗效和安全性分析

汤捷肖梅

汤捷　肖梅（解放军第八一医院　妇产科，南京　210000）

Comparative analysis of the effect of different doses of mifepristone treatment of endometriosis

TANG Jie, XIAO Mei

TANG Jie, XIAO Mei(The Department of Obstetrics and Gynecology, The No.81 Hospital of PLA, Nanjing 210000,China)

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摘要目的　比较不同剂量的米非司酮治疗子宫内膜异位症的疗效及安全性。方法　将南京市解放军第八一医院2012年1月至2014年1月患子宫内膜异位症的56例患者随机分为观察组与对照组，每组各28例，两组均予米非司酮口服治疗。其中观察组的剂量为5.0 mg/d，对照组的剂量为12.5 mg/d，共治疗6个月，比较两组的临床效果、复发率及安全性。结果　观察组和对照组总有效率及复发率的差异均无显著性（P>0.05）；观察组的不良反应发生率低于对照组（P<0.05）。结论　不同剂量米非司酮治疗子宫内膜异位症的疗效相当，但小剂量用药不良反应较少。

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关键词: font-size:14px 子宫内膜异位症；米非司酮；剂量；安全性')" href="#">">子宫内膜异位症；米非司酮；剂量；安全性

Abstract: Objective To compare the efficacy and safety of mifepristone therapy in endometriosis.Method　Divide 56 cases of patients suffering endometriosis in our hospital from Jan.2012 to Jan.2014 into observation group and control group randomly,each group contains 28 cases and both of them accept distinguish doses of oral mifepristone therapy.The doses for observation group and control group are 5.0mg/d and 12.5mg/d respectively,lasting for 6 months.Then make a conparison of clinical efficacy,recurrence rate and saftey between the two groups. Results　There is no significance of the total effective rate and recurrence rate between the two groups(P>0.05);the adverse reaction rate of treatment group is lower than that in reference group(P<0.05). Conclusions The efficacy of two kinds of doses of mifepristone is equivalent,however the small dose therapy represent less adverse reactions,which should be widely applied.

Key words: Endometriosis')" href="#">Endometriosis Mifepristone Dose Security

收稿日期: 2015-05-25 出版日期: 2015-10-30 发布日期: 2018-04-04 期的出版日期: 2015-10-30

通讯作者: 肖梅：https://baike.baidu.com/item/%E8%82%96%E6%A2%85/5851520?fr=aladdin E-mail: xiaomei2121@sohu.com

引用本文:

汤捷肖梅. 不同剂量米非司酮治疗子宫内膜异位症的疗效和安全性分析[J]. 发育医学电子杂志, 2015, 3(4): 229-232.
TANG Jie, XIAO Mei. Comparative analysis of the effect of different doses of mifepristone treatment of endometriosis. Journal of Developmental Medicine(Electronic Version), 2015, 3(4): 229-232.

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