Application of Katafuchi semi-quantitative criteria and the Oxford classification in children with IgA nephrology
RONG Li-ping, JIANG Meng-jie,MO Ying,et al
RONG Li-ping, JIANG Meng-jie,MO Ying,CHEN Li-zhi, XU Yuan-yuan, RUAN Jing-wei ,JIANG Xiaoyun( Department of Pediatrics, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Abstract: Objective To compare the differences and similarities of Katafuchi semi-quantitative criteria and the Oxford classification of IgA nephrology(IgAN) in scoring the degrees of glomerular and tubulointerstitial lesions in children with IgA neprology. Method Clinical and pathological data was retrospectively analyzed in 117 children with IgAN initially diagnosed by renal biopsy in the Department of pediatric nephrology, the First Affiliated Hospital of Sun Yat-sen University from June 2008 to June 2014. The degrees of glomerular and tubulointerstitial lesions were scored according to the Katafuchi semi-quantitative criteria and the Oxford classification of IgAN respectively.Results 117 children (male: 81 cases, female:36cases) with IgAN were included, The median age was 8.8 years（2.3~14.0）. All cases were divided into isolated haematuria group (18), hematuria and proteinuria group (52), acute glomerulonephritis (12) and nephrotic syndrome group (32) as well as into three groups according to pathologic grades according the 1982 Lee’s level criteria: grade Ⅰ+Ⅱ (19), grade Ⅲ (67) and grade Ⅳ+Ⅴ (31) groups. According to the Katafuchi semiquantitative critiria of IgAN, the severity scores of glomerullar and tubulo-interstitial lesions in pediatric patients were positively correlated with either different IgAN clinical or pathological groups(P<0.01). In the Oxford classification of IgAN, the severity scores of mesangial hypercellularity, endocapillary hypercellularity, tubular atrophy/interstitial fibrosis and segmental glomerulosclerosis/ adhension were positively correlated with different IgAN clinical groups (P<0.05). While in different IgAN pathological groups ,the severity of mesangial hypercellularity, endocapilarity hypercellularity, segmental glomerulosclerosis/adhension,tubular atrophy/intersitial fibrosis and cellular/fibrocellular crecents were all positively correlated with different IgAN pathological groups (P<0.05). Conclusions The severity scores of renal lesions according either Katafuchi semiquantitative critiria or the Oxford classification of IgAN were both positively correlated with different IgAN pathological groups, but it showed that Katafuchi semiquantitative critiria indicated a better positively correlationship with different IgAN clinical groups
容丽萍 姜梦婕 莫樱 陈丽植 许园园 阮静维 蒋小云. Katafuchi半定量评分系统和IgA肾病牛津病理分型在儿童IgA肾病的临床应用[J]. 发育医学电子杂志, 2015, 3(3): 145-151.
RONG Li-ping, JIANG Meng-jie, MO Ying, et al. Application of Katafuchi semi-quantitative criteria and the Oxford classification in children with IgA nephrology. Journal of Developmental Medicine(Electronic Version), 2015, 3(3): 145-151.
2015, Vol. 3 
