Clinical investigation for integrating Chinese-western therapy in the treatment of cholangitis after biliary atresia Kasai operation
ZHAO Yi-shan LI Yu-lan HAN Juan ZHAO Bao-hong LIU Wen-yue REN Hong-xia
1.Li Yulan Studio, Department of Pediatrics, Taiyuan Traditional Chinese Medicine Hospital, Shanxi, Taiyuan 030013, China; 2.Department of Neonatal Surgery, Children’s Hospital of Shanxi, Shanxi, Taiyuan 030013, China
Abstract: 【Abstract】 Objective To explore the clinical effect of integrating Chinese-western therapy in the treatment of cholangitis after biliary atresia Kasai operation. Methods From January 2014 to October 2017, 43 cases of children with first time of cholangitis were included and followed up in the Children's Hospital of Shanxi. All the children with jaundice who were diagnosed as biliary atresia by laparoscopic exploration and cholangiography performed laparotomy for Kasai surgery. A total of 20 cases with cholangitis were treated with conventional western medicine (control group). The other 23 cases withcholangitis were treated with traditional Chinese medicine Dachaihu decoction combined with western medicine routine treatment (study group). The basic conditions and alanine transferase (ALT), aspartate transaminase( AST), total bilirubin (TBIL) and direct bilirubin (DBIL) of pretherapy and post-treatment of the infants were compared between the two groups. Independent sample t test was used for statistical analysis. Results There was no statistical significance (both P>0.05) at the average age of surgery ［(65.8±7.3) vs (68.6±11.5) d］ and the onset date of cholangitis ［(107.1±8.7) vs (113.1±10.7) d］ in two groups. The following indicators in the study group were lower than that of in the control group: the time that body temperature dropped［(4.4±1.6) vs (8.3±1.5) d］, the time of the jaundice regression ［(9.0±1.2) vs(14.0±0.7) d］ and the length of hospital stay ［ (15.9±0.9) vs (19.5±1.0) d］(all P<0.05). There was no statistical significance in ALT ［(163.0±5.3) vs (164.6±8.8) U/L］ , AST ［(162.4±6.3) vs (164.0±5.9) U/L］, TBIL ［(107.0±2.9) vs (106.8±3.5) μmol/L］ and DBIL ［(72.9±5.3) vs (73.8±2.6) μmol/L］ between the two groups when the onset of cholangitis (all P>0.05). The AST and DBIL of the study group were lower than that of the control group ［AST (51.1±0.9) vs (54.6±0.9) U/L, DBIL (42.0±1.2) vs (45.5±0.9) μmol/L respectively］ at discharge (both P<0.05). Conclusion The addition of Dachaihu decoction on the basis of conventional western medicine treatment can reduce the body temperature effectively, accelerate the jaundice resolution and shorten the hospitalization time of children in the treatment of cholangitis after Kasai postoperative bile duct obstruction.
赵翊杉 李玉兰 韩娟 赵宝红 刘文跃 任红霞. 中西医结合治疗胆管闭锁 Kasai 术后胆管炎的临床研究[J]. 发育医学电子杂志, 2019, 7(1): 38-42.
ZHAO Yi-shan LI Yu-lan HAN Juan ZHAO Bao-hong LIU Wen-yue REN Hong-xia. Clinical investigation for integrating Chinese-western therapy in the treatment of cholangitis after biliary atresia Kasai operation. Journal of Developmental Medicine(Electronic Version), 2019, 7(1): 38-42.
2019, Vol. 7 
