Influence of pre-pregnant overweight on the gut microbiota of maternal and infants
LIU Xiao-feng, JIN Yu, QI Chen, GUAN Tao, GUO Yan-jie, GUAN Huai
1.Department of Obstetrics and Gynecology, No. 967 Hospital of PLA, Liaoning, Dalian 116021, China; 2.Department of Microecology, Dalian Medical University, Liaoning, Dalian 116044, China)
Abstract: 【Abstract】 Objective To collect the stool from newborn and pre-pregnant overweight women during the third trimester and compare that with normal weight women of pre-pregnant, and explore thecomposition of gut microflora. Methods From May 2017 to December 2018, a pair of 30 cases with pre-pregnant overweight (BMI >24.0 kg/m2) and pre-pregnant normal weight (BMI 18.5-24.0 kg/m2) were underwent prenatal examination and delivered in the No. 967 Hospital of PLA. Fecal samples of pregnant women (37-41 weeks) and neonates (3-4 days after birth) were collected and the total number of bifidobacterium, lactobacillus, enterococcus, enterobacter, yeast, bacteroides were detected by the approaches of qualitative and quantitative methods. The basic situations of mother's demographic, pregnancy complications, newborn birth weight and gender were analyzed and the composition of intestinal micro?ora was compared between two groups. The statistical analysis was performed by student t test and χ2 test. Results The group of pre-pregnant normal weight was lower than the group of pre-pregnant overweight in pre-pregnant BMI，age, the incidence rate of GDM. The birth weight of newborns in thepre-pregnant normal weight group was lower than that in the pre-pregnant overweight group. The number of bifidobacterium, lactobacillus and bacteroides of maternal gut in pre-pregnant overweigh group was lower than that in pre-pregnant normal weight group, whereas the number of enterobacter, enterococcus and yeast of maternal gut in pre-pregnant overweight group was higher than that in pre-pregnant normal weight group. There was statistical significance (all P<0.001). The number of bifidobacterium and lactobacillus of neonatal gut in pre-pregnant overweight group was lower than that in pre-pregnant normal weight group; whereas the number of enterobacter of neonatal gut in pre-pregnant overweight group was higher than that in pre-pregnant normal weight group. There was statistical significance (all P<0.001). Conclusions Maternal pre-pregnant overweight may in?uence the offspring's development through altering the gut microbiota of maternal and infants. Intervention of maternal gut microbiota during pregnancy may provide an opportunity to prevent the metabolic diseases of offspring.
刘晓峰 金玉 齐宸 管滔 郭艳杰 关怀. 孕前超重对母婴肠道菌群的影响[J]. 发育医学电子杂志, 2019, 7(2): 126-129.
LIU Xiao-feng, JIN Yu, QI Chen, GUAN Tao, GUO Yan-jie, GUAN Huai. Influence of pre-pregnant overweight on the gut microbiota of maternal and infants. Journal of Developmental Medicine(Electronic Version), 2019, 7(2): 126-129.
2019, Vol. 7 
