发育医学电子杂志 2020, Vol. 8 Issue (2): 112-114 DOI: 10.3969/j.issn.2095-5340.2020.02.004 |
围产医学
母源性疾病
|新生儿
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双胎输血综合征与围产儿脑损伤 |
马金旗 白瑞苗 李占魁 |
1. 西安医学院 研究生处,陕西 西安 710016; 2. 西北妇女儿童医院 新生儿科,陕西 西安 710061 |
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Twins transfusion syndrome and perinatal brain injury |
Ma Jinqi, Bai Ruimiao, Li Zhankui, et al |
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摘要 双胎输血综合征又称胎胎输血综合征(twinto-twin transfusion syndrome,TTTS),胎盘血管交通吻合支所致血循环不平衡是导致TTTS 的主要原因,是单绒毛膜双羊膜囊双胎(monochorionicdiamnionic twin,MCDA) 妊娠中一种特有的严重并发症[ 1]。MCDA中TTTS 的发生率为10% ~ 15%[1],如不予治疗,其围产期病死率可高达70% ~ 90%[2]。此外,研究显示双胎脑损伤是单胎脑损伤的7 倍,而MCDA 发生的颅内出血、脑白质损伤以及由此导致的远期脑损伤是双绒毛膜双胎的 7 倍[3]。TTTS 的发病机制尚不明确,双胎胎盘间有共同的血管床是双胎输血的解剖基础,血流的不平衡导致一系列的病理生理变化,致使脑损伤已在宫内发生。适时宫内干预,提高TTTS 的治疗技术,有助于从根源上降低脑损伤的发生。
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关键词:
font-size:14px
双胎输血综合征')" href="#">">双胎输血综合征
font-size:14px
单绒毛膜双羊膜囊双胎')" href="#">">单绒毛膜双羊膜囊双胎
font-size:14px
脑损伤')" href="#">">脑损伤
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收稿日期: 2019-12-03
出版日期: 2020-04-30
发布日期: 2020-04-22
期的出版日期: 2020-04-30
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基金资助: 陕西省科技厅重点研发项目(2018SF-070) |
通讯作者:
李占魁http://www.nwwch.com/info/1079/4430.htm
E-mail: lzk5808@163.com
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