The impact of oral contraceptives pretreatment on morbidity of early and late ovarian hyperstimulation syndrome after controlled ovarian hyperstimulation of different population
Reproductive Medicine Center，Tongji Hospital，Tongji Medicine College，Huazhong University of Scie，we and Technology，Wuhan 430030，China
Abstract: Abstract Objectives To study whether a cycle of oral contraceptives before pituitary downregulation could reduce the morbidity of ovarian hyperstimulation syndrome of different population after COH controlled ovarian hyperstimulation. Methods Data of 892 IVF/ICSI cycles with long GnRH-a scheme of pituitary down-regulation in luteal phase were collected from Feb.2013 to Jun.2013 in our reproductive center. We conducted a retrospective case-control study. The object of study was divided by antral follicular count into two groups of population, namely suspected high responders and non-suspected high responders. We compared the outcome of controlled ovarian hyperstimulation and the morbidity of ovarian hyperstimulaiton syndrome between patients with or without oral contraceptives pretreatment.Results As for the suspected high responders, oral contraceptives pretreatment could reduce the serum E2level30.1±13.6 vs 26.1±11.1, P <0.05, serum LH level1.5±0.7 vs 1.3±0.6P <0.05,LH/FSH ratio 0.5±0.2 vs 0.4±0.2P <0.05and also reduce the serum E2 level on the ovarian puncture day8065.9±3442.6 vs 6591.9±2940.2P <0.05and number of oocytes retrieved19.4 ±7.6 vs 17±7.8P <0.05. The OHSS morbidity is also significantly reduced53.6% vs 31.4%. As for the non-suspected high responders,OC pretreatment seems to have no effect on the COH outcome and the OHSS morbidity. Conclusion Of the suspected high responders, oral contraceptives pretreatment could suppress the high ovarian respond to a certain degree, which could reduce the LH/FSH ratio, serum E2 on the ovarian puncture day, follicular count before ovarian puncture and the number of oocytes retrieved. Thus, it could reduce the morbidity of ovarian hyperstimulaiton syndrome. Such effect of oral contraceptives was not found in terms of the non-suspected high responders in IVF/ICSI procedure.
王兰 董熙远 王睿 王亚 章汉旺. 口服避孕药预处理对不同人群控制性超促排卵过程中卵巢过度刺激综合征发病的影响[J]. 发育医学电子杂志, 2014, 2(2): 73-80.
WANG Lan, DONG Xi-yuan, WANG Rui, WANG Ya, ZHANG Han-wang. The impact of oral contraceptives pretreatment on morbidity of early and late ovarian hyperstimulation syndrome after controlled ovarian hyperstimulation of different population. Journal of Developmental Medicine(Electronic Version), 2014, 2(2): 73-80.
2014, Vol. 2 
