Abstract: 【Abstract】 objectiVes To establish trimeste卜as weU as before 9 weeks of pregllaIlcy—and method— specific semm reference interval for thyroid stimulating homone(rI’SH)，fke thymid hoHnones Fr4)，free three triiodothyronine(FT3)in local area．Methods According to the standards of National Academy of Clinical Biochemistry(NACB)，279 women in pre—pregnancy and 2946 in pregnancy period were screened to test semm FT3，FT4 and TSH level variation rate in each trimester aboVe．Results Both mean or median Value of TSH were decreased to a minimum at 8一l 1 weeks of gestation，established of the bottom，and then increased slo“y， retuming the pI℃一pregnancy level when perinatal period nearby；FT3 and FT4 also showed a reduction with the gestational age gmwth．Diagnosis with the reference interval of pre—pregnancy women would lead misjudge in about 4．8％TsH，15．1％FT3 and 50％I■’4 abnomalities in each pregnancy trimester．Conclusion Labomtory specific reference inteⅣal should be based on different experimentaI apparatus， methods，and service objects at di饪色rent gestation stages．Further study should focus on the possiblity of FT4 decline rates as a standard for Immunoassay method and reagent selection during pregnancy．
张宁 闰素文 徐斌 魏威 赵莹莹. 建立地区、孕龄和方法特异性甲状腺激素参考值范围在妊娠期甲状腺功能评价中的作用[J]. 发育医学电子杂志, 2013, 1(1): 23-27.
zHANG Ning YAN su—wen。XU Bin. The establishment Of
regiOnal，gestational age，method-specific thymidfuncti On referencerangesin the evaluatiOn
of thyroid functiOn during pregnancy. Journal of Developmental Medicine(Electronic Version), 2013, 1(1): 23-27.
2013, Vol. 1 
