Abstract: 【Abstract】 Objective To explore the clinical effect of endotracheal lavage with porcine pulmonary surfactant（PS） among newborns with severe meconium aspiration syndrome. Method 136 term infants with severe meconium aspiration syndrome from January, 2010 to June, 2013 were enrolled at our department. All the cases were stratified into 3 groups based on Apgar score of 0-3,4-7,and≥8，And then, all the 136 cases were randomly divided into two groups：PS endotracheal lavage group（lavage group ，68 cases） and PS intratracheal injection group（injection group ，68 cases）.Lavage group was treated with 3-5 ml PSattenuant every time（concentration：12 mg/ml）, while injection group with 200 mg/kg PS original fluid （first dose）.The data about Blood gas analysis,oxygen index（OI） and PaO2/ FiO2 （P/F）were collected and compared before treatment and 2h,12h,24h, and 48 h after treatment. The data about the duration of mechanical ventilation,the complication rate and the cure rate were also compared. Result There was no significant difference on PaO2,PaCO2,OI, P/F before treatment and 2 hours after treatment between the two groups （P>0.05）.Compared the data of 12h,24h,and 48h after treatment,the lavage group was better than injection group（P<0.01）.The duration of mechanical ventilation in lavage group（65.2±11.8）h was less than that in injection group（78.6±13.5）h（t=6.12, P＜0.01）.The cure rate of lavage group 66/68 cases （97.1%） was higher than that in injection group 60/68 cases （88.2%）（χ2=3.89，P＜0.05）.The complication rate of lavage group 2/68 cases （2.9%） was lower than that in injection group 9/68 cases （13.2%） （χ2=4.85， P＜0.05）. Conclusion The clinical effect of endotracheal lavage with PS attenuant is better than intratracheal injection with PS original fluid on improving ventilation and oxygenation efficiency, and also can decrease the duration of mechanical ventilation and the complication rate,while increase the cure rate. The method of endotracheal lavage with PS attenuant is safe, effective and worth widely using in clinical treatment.
林新祝 赖基栋 兰朝阳 林雅茵. 猪肺表面活性物质气管内灌洗治疗重症新生儿胎粪吸入综合征的临床研究[J]. 发育医学电子杂志, 2014, 2(1): 16-20.
LIN Xin-zhu, LAI Ji-dong, LAN Zhao-yang, et al. Clinical study of endotracheal lavage with porcine pulmonary surfactant with severe meconium aspiration syndrome. Journal of Developmental Medicine(Electronic Version), 2014, 2(1): 16-20.
2014, Vol. 2 
