环状RNAs在先天性肛门直肠畸形相关基因及通路的研究进展

doi:10.3969/j.issn.2095-5340.2019.04.013

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发育医学电子杂志

2019, Vol. 7

Issue (4): 302-309 DOI: 10.3969/j.issn.2095-5340.2019.04.013

结构畸形综述

环状RNAs在先天性肛门直肠畸形相关基因及通路的研究进展

刘丹　贾慧敏

中国医科大学附属盛京医院　小儿外科，辽宁　沈阳　110004

The advances of circular RNAs on genes and pathways in anorectal malformations

LIU Dan, JIA Hui-min

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摘要先天性肛门直肠畸形（congenital anorectal malformations，ARMs）是小儿外科常见消化道畸形之一，其发病率为1/（5 000～1 500）^［1］，产前诊断多难发现，大部分在新生儿期才可做出诊断。据统计，男性发病率略高于女性^［2］，且50%以上患儿常合并泌尿生殖系统、心血管系统、骨骼及胃肠道畸形^［3-4］。ARMs是由多个基因与数种环境因素共同作用产生的，支配肛门直肠形成过程中的任何基因或通路发生突变或异常都可能导致ARMs^［5］。

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收稿日期: 2019-05-18 出版日期: 2019-10-30 发布日期: 2019-11-14 期的出版日期: 2019-10-30

基金资助: 国家自然科学基金（81671503）

通讯作者: 贾慧敏http://www.sj-hospital.org/show.php?mesid=3214 E-mail: jiahuiminmm@163.com

引用本文:

刘丹　贾慧敏. 环状RNAs在先天性肛门直肠畸形相关基因及通路的研究进展[J]. 发育医学电子杂志, 2019, 7(4): 302-309.
LIU Dan, JIA Hui-min. The advances of circular RNAs on genes and pathways in anorectal malformations. Journal of Developmental Medicine(Electronic Version), 2019, 7(4): 302-309.

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