发育医学电子杂志 Vol. 3 241-245
生长发育
临床经验交流
丙基硫氧嘧啶致儿童继发性抗中性粒细胞 胞质抗体相关性小血管炎1例
史卓 孙涛 夏正坤
史卓 孙涛 夏正坤（南京军区南京总医院 儿科,南京 210002）
Propylthioouracil-associated antineutrophil cytoplasmic antibody-positive vasculitis: 1 case report and review of literature
SHI Zhuo,SUN Tao,XIA Zheng-kun
SHI Zhuo,SUN Tao,XIA Zheng-kun(Department of Pediatrics, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China)
摘要 目的 分析丙基硫氧嘧啶(PTU )致抗中性粒细胞质抗体（ANCA ）相关性小血管炎的机制。方法 采用1 例长期服用PTU 患儿所致ANCA 相关性小血管炎的临床资料。结果 患儿因贫血、蛋白尿、肾功能不全，伴有咯血而就诊,追问病史发现其发病前曾服用PTU 3年，经免疫抑制、血浆置换等治疗后症状缓解，肾功能改善。结论 PTU 可引起 A NCA 相关性小血管炎，及时停用相关药物以及应用免疫抑制剂、血浆置换等治疗，可使病情缓解。
关键词:
font-size:14px 肾功能不全；丙基硫氧嘧啶；血管炎')" href="#">">肾功能不全；丙基硫氧嘧啶；血管炎
Abstract: Objective To analyze pathogenesis of antineutrophil cytoplasmic antibody-positive vasculitis induced by propylthiouracil (PTU).Method By reporting a case of Antineutrophil Cytoplasmic Antibody-positive Vasculitis induced by PTU. Results The patient (who had been treated with PTU for 3 years because of hyperthyreosis) presented with hypohemia, proteinuria, renal function damage, injury of lungs, positive Antineutrophil Cytoplasmic Antibody.After immunosuppressive therapy, plasma exchange and other treatment, the symptoms of the patients were relieved and the renal function was restored. Conclusions PTU may induce Antineutrophil Cytoplasmic Antibody-positive Vasculitis. Early diagnosis, withdraw of ptu, plasma exchange and administration of glucocortocoid can improve its prognosis.
Key words:
Renal insufficiency')" href="#">Renal insufficiency
Propylthiouracil
Vasculitis
收稿日期: 2015-03-11
出版日期: 2015-10-30
发布日期: 2018-04-09
期的出版日期: 2015-10-30
通讯作者:
夏正坤：https://baike.baidu.com/item/%E5%A4%8F%E6%AD%A3%E5%9D%A4
E-mail: njxzk@126.com
引用本文:
史卓 孙涛 夏正坤. 丙基硫氧嘧啶致儿童继发性抗中性粒细胞 胞质抗体相关性小血管炎1例 [J]. 发育医学电子杂志, 2015, 3(4): 241-245.
Propylthioouracil-associated antineutrophil cytoplasmic antibody-positive vasculitis: 1 case report and review of literature . Journal of Developmental Medicine(Electronic Version), 2015, 3(4): 241-245.
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