发育医学电子杂志 2016, Vol. 4 Issue (4): 247-252
生长发育
综述
|
脓毒症遗传易感性的研究现状与进展
封志纯 余帮
封志纯 余帮(陆军总医院附属八一儿童医院 儿童重症监护中心,北京 100700)
Research status and advances on genetic susceptibility to sepsis #br#
FENG Zhi-chun, YU Bang
摘要 脓毒症(sepsis )是指感染所致的全身炎症反应综合征(systemic inflammatory response syndrome,SIRS )。入侵机体的病原微生物可以是细菌、病毒、支原体、真菌或寄生虫等,其中以细菌最常见。感染刺激机体产生炎症反应,机体内源性免疫炎性因子大量释放而形成“瀑布效应”,超出机体代偿能力时机体出现过度的炎症反应,引起广泛的组织细胞损伤,即SIRS 。严重脓毒症还可导致机体免疫功能紊乱,凝血纤溶系统激活和微循环障碍,从而继发脓毒性休克、弥散性血管内凝血(disseminated intravascular coagulation,DIC )和多器官功能障碍 综合征(multiple organ dysfunction syndrome,MODS ),病死率高,是威胁人类健康的重大疾病。
关键词:
font-size:14px
脓毒症 ">脓毒症 font-size:14px
疾病遗传易感性')" href="#">">疾病遗传易感性
收稿日期: 2016-06-02
出版日期: 2016-10-30
发布日期: 2018-01-24
期的出版日期: 2016-10-30
基金资助: 中国博士后科学基金(20100471758)
通讯作者:
封志纯:https://baike.baidu.com/item/%E5%B0%81%E5%BF%97%E7%BA%AF/9328206?fr=aladdin
E-mail: zhjfengzc@126.com
[1]
GAO Xiao-hui, MAO Jian. Clinical features of non-oliguric hyperkalemia in extremely low birth weight infants [J]. Journal of Developmental Medicine(Electronic Version), 0, (): 152
.
[2]
Society of Neonatologist, Chinese Medical Doctor Association. Consensus recommendations on the prevention and early management of respiratory distress syndrome in preterm infants [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 129
-131
.
[3]
Professional Committee of Respiratory, Society of Neonatologist, Chinese Medical Doctor Association. Clinical application recommendations for heated humidified high flow nasal cannula [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 132
-135
.
[4]
YAN Jun, ZHU Xing-wang, SHI Yuan. Application progress of noninvasive ventilate technique for premature infants [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 136
-140
.
[5]
GU Min-fang, YANG Chuan-zhong. Progress of intrapartum resuscitation for premature infants [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 141
-145
.
[6]
LIU Shu-hua, SHEN Yue-bo, LIU Cui-qing, MA Li. The efficacy of pulmonary surfactant for pulmonary function in premature tension pneumothorax [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 146
-151
.
[7]
GAO Xiao-hui, MAO Jian. Clinical features of non-oliguric hyperkalemia in extremely low birth weight infants [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 152
-158
.
[8]
XIA Yao-fang, YANG Juan , TIAN Bao-li, et al. Value of amplitude-integrated electroencephalography in monitoring acute period of neonatal bilirubin encephalopathy and prognostic assessment [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 159
-163
.
[9]
WANG Li-rong, SUN Xiao-yan, ZHU Ruo-xin, et al. Epidemiological investigation and analysis of women aged 40-55 years old with osteoporosis in Gansu province [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 164
-167
.
[10]
CHEN Ru-yue, SHEN Yun-yan, CHEN Qing , et al. Five cases about Henoch-Schönlein purpura complicated with central nervous system injury in children and literatures review [J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 168
-171
.
Viewed
Full text
Abstract
Cited
Shared
Discussed